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Critical Care General

Inhaled Sedation: A Promising Treatment for Severe ARDS in COVID-19 Patients

Apr 19, 2023

The following is a summary of "Usefulness of Inhaled Sedation in Patients With Severe ARDS Due to COVID-19," published in the March 2023 issue of Respiratory Care by Duque et al.  The administ...

Modeling Optimal Tracheostomy Timing Based on Vocal Cord Injury Severity

Apr 18, 2023

The following is a summary of the “Optimal Tracheostomy Timing Through Modeling Based on Severity of Vocal Cord Injury,” published in the February 2023 issue of Respiratory Care by Malkoc, et al. ...

Yap1-Usp14 Axis Inhibits Neuronal Mitophagy During Neonatal Hypoxia-Ischemia Encephalopathy by Regulation of Beclin-1 Ubiquitination in Mouse.

Apr 17, 2023

Neonatal hypoxic-ischemic encephalopathy (HIE) that results from perinatal cerebral hypoxia-ischemia has become one of the leading causes of acute mortality and chronic disability in infants and child...

Survival of Streptococcus equi subsp. zooepidemicus on environmental samples is affected by material type and incubation temperature.

Apr 17, 2023

Streptococcus equi subsp. zooepidemicus is an opportunistic pathogen associated with disease in a range of domestic and wild animals. Despite its importance, very limited data is available on its surv...

CRISPR/Cas9-based point-of-care lateral flow biosensor with improved performance for rapid and robust detection of Mycoplasma pneumonia.

Apr 17, 2023

Screening of acute respiratory infections causes serious challenges in urgent point-of-care scenarios where conventional methods are impractical and alternative techniques suffer from low accuracy, po...

EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.

Apr 17, 2023

Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses ...

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect.

Apr 17, 2023

Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, for which effective therapeutic strategies are still absent. Shengjiang San (SJS), a well-known Tradi...

Hippocampal demyelination is associated with increased magnetic susceptibility in a mouse model of concussion.

Apr 17, 2023

Structural and functional deficits in the hippocampus are a prominent feature of moderate-severe traumatic brain injury (TBI). In this work, we investigated the potential of Quantitative Susceptibilit...

Mortality Prediction in Severe Traumatic Brain Injury Using Traditional and Machine Learning Algorithms.

Apr 17, 2023

Prognostic prediction of traumatic brain injury (TBI) in patients is crucial in clinical decision and health care policy making. This study aimed to develop and validate prediction models for in-hospi...

Comparing Direct Extubation to HFNC with NIV in Obese Patients

Apr 11, 2023

The following is a summary of the "Direct Extubation to High-Flow Nasal Cannula versus Noninvasive Ventilation in Obese Subjects," published in the February 2023 issue of Respiratory Care by Magdy, et...

Tools to differentiate between Filamin C and Titin truncating variant carriers: value of MRI.

Apr 10, 2023

Whereas truncating variants of the giant protein Titin (TTNtv) are the main cause of familial dilated cardiomyopathy (DCM), recently Filamin C truncating variants (FLNCtv) were identified as a cause o...

A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury.

Apr 10, 2023

The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ inju...

Aseptic presentation of interventricular septal abscess with progressive heart block: a case report.

Apr 10, 2023

Infective endocarditis can progress to an intracardiac abscess in 20% to 30% of cases, with interventricular septal abscess (IVSA) being one of the rare complications usually presenting with sepsis. W...

Disturbances in fear extinction learning after mild traumatic brain injury in mice are accompanied by alterations in dendritic plasticity in the medial prefrontal cortex and basolateral nucleus of the amygdala.

Apr 10, 2023

Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) have emerged as the signature injuries of the U.S. veterans who served in Iraq and Afghanistan, and frequently co-occur in ...

Current status and outlook for the management of intracranial hypertension after traumatic brain injury: decompressive craniectomy, therapeutic hypothermia, and barbiturates.

Apr 10, 2023

Increased intracranial pressure (ICP) has been associated with poor neurological outcomes and increased mortality in patients with severe traumatic brain injury (TBI). Traditionally, ICP-lowering ther...

[Clinical observation of Qiliqiangxin capsule combined with recombinant human brain natriuretic peptide in patients with acute heart failure].

Apr 10, 2023

To observe the clinical effect of Qiliqiangxin capsule combined with recombinant human brain natriuretic peptide in acute left heart failure patients 7 days after onset as well as the effects of plas...

Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy.

Apr 10, 2023

The muscular dystrophies caused by dystrophin deficiency, the so-called dystrophinopathies, are associated with impaired cardiac contractility and arrhythmias, which considerably contribute to disease...

Multiple-site decontamination to prevent acquired infection in patients with veno-venous ECMO support.

Apr 10, 2023

Acute distress respiratory syndrome (ARDS) patients with veno-venous extra corporeal membrane oxygenation (ECMO) support are particularly exposed to ECMO-associated infection (ECMO-AI). Unfortunately,...

Recirculation System for CPAP: Reducing Oxygen Consumption

Apr 06, 2023

The following is a summary of the “A Recirculation System to Reduce the Consumption of Oxygen During CPAP,” published in the February 2023 issue of Respiratory Care by Coppadoro, et al. A h...

Study of the Gut's Essential Function in Intensive Care Settings

Apr 05, 2023

The following is the summary of “Central role of the gut in intensive care” published in the December 2022 issue of Critical care by Corriero, et al. Patients who are critically ill are mor...

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