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Pain General

Understanding sedative effects within the context of acute Neuroinflammation in the developing brain: Potential induction of delirium-like behaviors.

Jun 12, 2023

Neurologic morbidity is highly prevalent in pediatric critical illness, and the use of benzodiazepines and/or opioids are risk factors for delirium and post-discharge sequelae. However, little is know...

Cervicogenic headache.

Jun 12, 2023

Cervicogenic headache, first proposed as a distinct headache in 1983, is a secondary headache to a primary cervical musculoskeletal disorder. Research into physical impairments was integral to clinica...

The Registry for Migraine (REFORM) study: methodology, demographics, and baseline clinical characteristics.

Jun 12, 2023

Erenumab has demonstrated effectiveness for prevention of migraine attacks, but the treatment is costly, and a considerable proportion of patients do not respond to it. The Registry for Migraine study...

How Does Meditation-Based Lifestyle Modification Affect Pain Intensity, Pain Self-Efficacy, and Quality of Life in Chronic Pain Patients? An Experimental Single-Case Study.

Jun 12, 2023

Chronic pain is a growing worldwide health problem and complementary and integrative therapy options are becoming increasingly important. Multi-component yoga interventions represent such an integrati...

Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions - A Scoping Review.

Jun 12, 2023

At low doses, naltrexone (LDN) has been shown to modulate inflammation through the interruption of microglial cell activation within the central nervous system. One of the most likely contributors to ...

Causal association of rheumatoid arthritis with obstructive lung disease: Evidence from Mendelian randomization study.

Jun 12, 2023

Observational studies have found an association between rheumatoid arthritis (RA) and risk of obstructive lung disease (ORDs). However, whether RA plays a role in ORDs development remains unclear.This...

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets.

Jun 12, 2023

Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint dysfunction wit...

Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care.

Jun 12, 2023

Pain neuroscience education combined with exercise (PNE + exercise) is an effective treatment for patients with chronic spinal pain. Yet, however, little is known about its underlying therapeutic mech...

Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia.

Jun 12, 2023

Referred sensation (RS) as a specific clinical phenomenon has been known for a long time, although the underlying mechanisms remain unclear. The aims of this study were to assess if (1) healthy indivi...

Inequities in the treatment of opioid use disorder: A scoping review.

Jun 05, 2023

Given the lack of access to evidenced-based OUD treatment and the corresponding overdose crisis, researchers must evaluate and report health care inequities involving the treatment of OUD. Additionall...

Intra-articular injections of biological disease-modifying anti-rheumatic drugs in inflammatory arthropathies: an up-to-date narrative review.

Jun 05, 2023

Since the 1990s bDMARDs have revolutionized the treatment of chronic dysimmune inflammatory arthropathies such as Rheumatoid Arthritis, Psoriatic Arthritis and Axial Spondylarthritis. Nevertheless, de...

No Evidence that Working Memory Modulates the Plasticity of the Nociceptive System, as Measured by Secondary Mechanical Hypersensitivity.

Jun 05, 2023

The effect of cognition on the plasticity of the nociceptive system remains controversial. In this study, we examined whether working memory can buffer against the development of secondary hypersensit...

Modulation of thalamocingulate nociceptive transmission and glutamate secretion by targeting P2X7 receptor.

Jun 05, 2023

The complexity and diversity of pain signaling have led to obstacles for prominent treatments due to mechanisms that are not yet fully understood. Among adenosine triphosphate (ATP) receptors, P2X7 di...

Multimodal hypersensitivity derived from quantitative sensory testing predicts pelvic pain outcome: an observational cohort study.

May 29, 2023

Multimodal hypersensitivity (MMH)-greater sensitivity across multiple sensory modalities (eg, light, sound, temperature, pressure)-is associated with the development of chronic pain. However, previous...

Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group.

May 29, 2023

Pain radiating from the spine into the leg is commonly referred to as "sciatica," "Sciatica" may include various conditions such as radicular pain or painful radiculopathy. It may be associated with s...

Joint and muscle inflammatory disease: A scoping review of the published evidence.

May 22, 2023

Polyarthritis is commonly reported in idiopathic inflammatory myositis patients, but few studies have focused on the overlap of myositis with rheumatoid arthritis which is a difficult diagnosis in the...

Pain control beliefs predict premature withdrawal from the labor market in workers with persistent pain: Prospective cohort study with 11-year register follow-up.

May 22, 2023

While a range of work-related psychosocial factors have been associated with various pain disorders and early retirement, less is known about pain cognitions and their influence on premature exit from...

Obesity, adipokines, and chronic and persistent pain in rheumatoid arthritis.

May 22, 2023

We aimed to determine whether adipokines are associated with pain and polysymptomatic distress in patients with rheumatoid arthritis (RA) over time in a large patient registry. The cohort study was co...

Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.

May 15, 2023

To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use.As part of the Environmental influences on Child Health Outcomes (ECHO) Program, we harmon...

Association between methylation in the promoter region of the GAD2 gene and opioid use disorder.

May 15, 2023

DNA methylation is one of the epigenetic mechanisms involved in opioid use disorder. GAD2 is a key catalyticase in gamma amino butyric acid (GABA) synthesis from glutamate, that is implicated in opioi...

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