Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.

May 15, 2023

Experts: Sarah E Maylott,Elisabeth Conradt,Monica McGrath,Emily A Knapp,Xiuhong Li,Rashelle Musci,Judy Aschner,Lyndsay A Avalos,Lisa A Croen,Sean Deoni,Karen Derefinko,Amy Elliott,Julie A Hofheimer,Leslie D Leve,Juliette C Madan,Maxwell A Mansolf,Liza B Murrison,Jenae M Neiderhiser,Sally Ozonoff,Jonathan Posner,Amy Salisbury,Sheela Sathyanarayana,Julie B Schweitzer,Carl Seashore,Meagan E Stabler,Leslie W Young,Steven J Ondersma,Barry Lester,

To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use.
As part of the Environmental influences on Child Health Outcomes (ECHO) Program, we harmonized prenatal substance use data and child behavior outcomes from 2,195 women and their 6- to 11-year-old children across 10 cohorts in the United States and used latent class-adjusted regression models to predict parent-rated child behavior.
Three latent classes fit the data: low use (90.5%; n=1,986), primarily using no substances; licit use (6.6%; n=145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n=64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had higher levels of externalizing behavior than children exposed to low or no substances (p=.001, d=.64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (p<.001, d=.16).
The differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multi-cohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.

Copyright © 2023 Elsevier Inc. All rights reserved.

Author

admin

View all posts

ABOUT THE EXPERTS

Sarah E Maylott,Elisabeth Conradt,Monica McGrath,Emily A Knapp,Xiuhong Li,Rashelle Musci,Judy Aschner,Lyndsay A Avalos,Lisa A Croen,Sean Deoni,Karen Derefinko,Amy Elliott,Julie A Hofheimer,Leslie D Leve,Juliette C Madan,Maxwell A Mansolf,Liza B Murrison,Jenae M Neiderhiser,Sally Ozonoff,Jonathan Posner,Amy Salisbury,Sheela Sathyanarayana,Julie B Schweitzer,Carl Seashore,Meagan E Stabler,Leslie W Young,Steven J Ondersma,Barry Lester,

Sarah E Maylott

Duke University, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina; Department of Psychology, University of Utah, Salt Lake City, Utah. Electronic address: sarah.maylott@duke.edu.

Elisabeth Conradt

Duke University, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina; Department of Psychology, University of Utah, Salt Lake City, Utah.

Monica McGrath

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.

Emily A Knapp

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.

Xiuhong Li

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland.

Rashelle Musci

Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland.

Judy Aschner

Department of Pediatrics, Hackensack Meridian School of Medicine, Nutley, New Jersey; Albert Einstein College of Medicine, Bronx, New York.

Lyndsay A Avalos

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Lisa A Croen

Division of Research, Kaiser Permanente Northern California, Oakland, California.

Sean Deoni

Department of Pediatrics and Department of Diagnostic Imaging, Alpert Medical School of Brown University, Providence, Rhode Island.

Karen Derefinko

Department of Preventive Medicine and Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, Tennessee.

Amy Elliott

Avera Research Institute and Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, South Dakota.

Julie A Hofheimer

Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, North Carolina.

Leslie D Leve

Prevention Science Institute, University of Oregon, Eugene, Oregon.

Juliette C Madan

Department of Pediatrics, Psychiatry and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Maxwell A Mansolf

Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Liza B Murrison

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.

Jenae M Neiderhiser

Department of Psychology, Penn State University, University Park, Pennsylvania.

Sally Ozonoff

Department of Psychiatry and Behavioral Sciences, University of California, Davis, California.

Jonathan Posner

Duke University, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina.

Amy Salisbury

School of Nursing, Virginia Commonwealth University, Richmond, Virginia.

Sheela Sathyanarayana

Departments of Pediatrics, Environmental and Occupational Health Sciences, and Epidemiology, University of Washington, Seattle, Washington, Seattle Children’s Research Institute, Seattle, Washington.

Julie B Schweitzer

Department of Psychiatry and Behavioral Sciences and the MIND Institute, University of California, Davis, School of Medicine, Sacramento, California.

Carl Seashore

Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, North Carolina.

Meagan E Stabler

Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, New Hampshire.

Leslie W Young

Department of Pediatrics, University of Vermont Medical Center, Burlington, Vermont.

Steven J Ondersma

Division of Public Health and Department of Obstetrics, Gynecology, & Reproductive Biology, Michigan State University, East Lansing, Michigan.

Barry Lester

Center for the Study of Children at Risk, Departments of Psychiatry and Pediatrics, Alpert Medical School of Brown University and Women and Infants Hospital, Providence, Rhode Island.