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Pain General

Surgical Intervention is Associated with Improved Outcomes in Patients with Symptomatic Cervical Spine Tarlov Cysts: Results from a Prospective Cohort Study.

Oct 23, 2023

Tarlov cysts are known contributors to radiculopathy but are often misdiagnosed and mismanaged due to a paucity of information. This is particularly true of cervical spine Tarlov cysts since most atte...

Functional implications of rs9373441 with FOXP3+Treg and Tr1 for the clinical effectiveness of csDMARDs in Rheumatoid arthritis.

Oct 23, 2023

Rheumatoid arthritis (RA) is characterized by a deficiency in regulatory T cells (Treg), which play a crucial role in immune regulation. While conventional synthetic disease-modifying antirheumatic dr...

Enhanced intra-articular therapy for rheumatoid arthritis using click-crosslinked hyaluronic acid hydrogels loaded with toll-like receptor antagonizing peptides.

Oct 23, 2023

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that results in the deterioration of joint cartilage and bone. Toll-like receptor 4 (TLR4) has been pinpointed as a key factor in RA-relate...

Cannabidiol (CBD) products for pain: ineffective, expensive, and with potential harms.

Oct 23, 2023

Cannabidiol (CBD) attracts considerable attention for promoting good health and treating various conditions, predominantly pain, often in breach of advertising rules. Examination of available CBD prod...

The impact of the transversus abdominis plane block (TAP) on stress response measured through the complete blood- derived inflammatory markers.

Oct 16, 2023

This study aims to evaluate the effect of the transversus abdominis plane (TAP) block on the blood cells and the inflammatory markers neutrophil- to- lymphocyte ratio (NLR), platelet- to- lymphocyte r...

Low Daily Step Count Associated with Small Erector Spine Muscle Area and Sarcopenia in Idiopathic Pulmonary Fibrosis.

Oct 16, 2023

Objective The daily step count is associated with mortality in idiopathic pulmonary fibrosis (IPF). However, the factors associated with this phenomenon are not yet fully understood. We therefore clar...

The Medication Quantification Scale 4.0: An updated index based on prescribers' perceptions of the risk associated with chronic pain medications.

Oct 16, 2023

To quantify risks associated with drug utilization in the real world for the treatment of chronic pain (CP), an index called the Medication Quantification Scale (MQS) was developed in 1992 in the Unit...

Proteomic Analysis to Identify Prospective Biomarkers of Treatment Outcome After Microvascular Decompression for Trigeminal Neuralgia: A Preliminary Study.

Oct 16, 2023

Trigeminal neuralgia (TN) is a severe neuropathic facial pain disorder, often caused by vascular or neuronal compression of the trigeminal nerve. In such cases, microvascular decompression (MVD) surge...

Skin Decontamination of Carfentanil in vitro.

Oct 09, 2023

Skin decontamination of Chemical Biological Radioactive and Nuclear (CBRN) materials involves the timely and effective removal of the contaminants from the skin surface. The current work evaluated Ful...

Neurobiological correlation between phosphorylated tau and mood symptoms in memory clinic patients.

Oct 09, 2023

Alzheimer's disease (AD) dementia and mild cognitive impairment are characterised by impaired cognition accompanied by neuropsychiatric symptoms (NPS) relating to mood, including depression, anxiety, ...

Wnt5a: A promising therapeutic target for inflammation, especially rheumatoid arthritis.

Oct 09, 2023

Wnt5a is a member of the Wnt protein family, which acts on classical or multiple non-classical Wnt signaling pathways by binding to different receptors. The expression regulation and signal transducti...

Hyper negative GABA reversal potential in pyramidal cells contributes to medial prefrontal cortex deactivation in a mouse model of neuropathic pain.

Oct 09, 2023

Deactivation of medial prefrontal cortex (mPFC) has been broadly reported in both neuropathic pain models and human chronic pain patients. Several cellular mechanisms may contribute to the inhibition ...

A Personalized Protocol for Prescribing Opioids After Cesarean Delivery: Leveraging the Electronic Medical Record to Reduce Outpatient Opioid Prescriptions.

Oct 02, 2023

Though cesarean delivery is the most common surgery performed in the United States, prescribing practices for analgesia vary. Strategies to manage postpartum pain have mostly focused on the immediate ...

Medications for opioid use disorder prescribed at hospital discharge associated with decreased opioid agonist dispensing in patients with opioid use disorder requiring critical care: A retrospective study.

Oct 02, 2023

Buprenorphine is highly effective for the treatment of opioid use disorder (OUD), and, in recent years, the rates of patients maintained on buprenorphine requiring critical care have been steadily inc...

Racial Disparities in Opioid Use and Lumbar Spine Surgery for Chronic Pain and in Pain and Function over Three Years: A Retrospective Cohort Study.

Oct 02, 2023

This study aims to compare treatments and outcomes among Black and White patients with chronic low back pain in the United States. A retrospective cohort study was conducted within a pain research reg...

Prognosis of patients with neuropathic low back-related leg pain: An exploratory study using prospective data from UK primary care.

Oct 02, 2023

This prospective cohort study investigates the prognosis of patients with neuropathic low back-related leg pain (LBLP) consulting in UK primary care. Data from 511 patients were collected using standa...

Patient Controlled Subcutaneous Analgesia of Hydromorphone Versus Morphine to Treat Moderate and Severe Cancer Pain: A Randomized Double-Blind Controlled Trial.

Sep 25, 2023

Hydromorphone and morphine are the common drugs used for the treatment of moderate to severe cancer pain. Patient controlled subcutaneous analgesia (PCSA) is an effective technique to manage cancer pa...

Traumatic Injuries and Radiographic Study Utilization Among Children with Drowning Presenting to U.S. Pediatric Hospitals.

Sep 25, 2023

The role of traumatic injuries in fatal and non-fatal drownings is poorly described. We sought to characterize the incidence of traumatic injuries and diagnostic imaging performed among children who r...

PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis.

Sep 25, 2023

Ankylosing spondylitis (AS) is a common inflammatory arthritis without a reliable biomarker. The role of methylation and mRNA expression of PRICKLE1 promoter in the pathogenesis of ankylosing spondyli...

"Buprenorphine, It Works so Differently": Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain.

Sep 25, 2023

A growing body of literature describes the use of buprenorphine for the treatment of chronic pain in people with sickle cell disease. The experiences of people with sickle cell disease who have tried ...

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