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Ophthalmology General

Ophthalmology training in sub-Saharan Africa: a scoping review.

Dec 21, 2020

Sub-Saharan Africa is home to 12% of the global population, and 4.3 million are blind and over 15 million are visually impaired. There are only 2.5 ophthalmologists per million people in SSA. Training...

Surgical Grade and Repeat Laser Peripheral Iridotomy Procedures with Risk Stratification and Educational Considerations.

Dec 21, 2020

Peripheral laser iridotomy (PLI) is a commonly performed procedure. While effective, repeat procedures (RPs) may be required for a variety of causes. We report the causes and rate of RP PLI and whethe...

Social cognition in the blind brain: A coordinate-based meta-analysis.

Dec 17, 2020

Social cognition skills are typically acquired on the basis of visual information (e.g., the observation of gaze, facial expressions, gestures). In light of this, a critical issue is whether and how t...

Various cross-linking methods inhibit the collagenase I degradation of rabbit scleral tissue.

Dec 17, 2020

Collagen cross-linking of the sclera is a promising approach to strengthen scleral rigidity and thus to inhibit eye growth in progressive myopia. Additionally, cross-linking might inhibit degrading pr...

Dysfunction of VIPR2 leads to myopia in humans and mice.

Dec 17, 2020

Myopia is the leading cause of refractive errors. As its pathogenesis is poorly understood, we determined if the retinal VIP-VIPR2 signalling pathway axis has a role in controlling signalling output t...

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic.

Dec 17, 2020

Homocystinuria due to cystathionine β-synthase (CBS) deficiency, the most frequent inborn error of sulfur amino acid metabolism, is characterized biochemically by severely elevated homocysteine (Hcy)...

Molecular Pharmacology of P2Y Receptor Subtypes.

Dec 17, 2020

Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1 and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular adenine and uracil nucleotide...

Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research.

Dec 17, 2020

Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in d...

Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.

Dec 17, 2020

Diabetic retinopathy is characterised by retinal neurodegeneration and retinal vascular abnormalities, affecting one third of diabetic patients with disease duration of more than 10 years. Accumulate...

Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.

Dec 17, 2020

Vitreous hemorrhage from proliferative diabetic retinopathy can cause loss of vision. The best management approach is unknown.To compare initial treatment with intravitreous aflibercept vs vitrectomy ...

Ophthalmic Drops with Nanoparticles Derived from a Natural Product for Treating Age-Related Macular Degeneration.

Dec 17, 2020

There is a continuing, urgent need for an ophthalmic (eye) drop for the clinical therapy of age-related macular degeneration (AMD), a leading cause of blindness. Here, we report the first formulation ...

Comparison of Clinical Outcomes with Open Versus Closed Conjunctiva Implantation of the XEN45 Gel Stent.

Dec 17, 2020

To describe the efficacy and safety of open versus closed conjunctival implantation of the XEN45 Gel Stent.Retrospective multicenter study.137 patients with glaucoma who underwent XEN45 implantation v...

Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions.

Dec 17, 2020

Age-related macular degeneration (AMD) remains a significant cause of legal blindness, and treatment for the geographic atrophy form of AMD is a significant unmet need. Dysregulation of the complement...

A polygenic risk score predicts intraocular pressure readings outside office hours and early morning spikes as measured by home tonometry.

Dec 17, 2020

Intraocular pressure (IOP) elevations may occur in early morning or outside office hours and can be missed during routine in-clinic IOP measurements. Such fluctuations or peaks likely contribute to gl...

Effect of fundus tracking on structure-function relationship in glaucoma

Dec 15, 2020

Researchers did this study to investigate the effect of fundus tracking perimetry on structure-function relationship in glaucoma. The researchers included data from 696 eyes from 360 healthy people a...

Acceptability, adherence, and economic analyses of a new clinical pathway

Dec 14, 2020

The researchers did this study to assess whether a new clinical pathway for glaucoma was acceptable to patients and healthcare professionals and whether it provided useful clinical information on non-...

The usefulness of data augmentation for visual field trend analyses

Dec 14, 2020

The researchers conducted this research to investigate the usefulness of data augmentation in the VF trend analyses in patients with glaucoma. This study included a total of 6380 VFs from 638 eyes of...

Visual field progression eight years after trabeculectomy in Asian eyes

Dec 14, 2020

This work aimed to study the effect of long-term IOP fluctuation on the VF progression eight years post-trabeculectomy in Asian eyes. The present study was a retrospective analysis of 8-year post-tra...

Posterior corneal features in patients with Down syndrome

Dec 14, 2020

Researchers did this study to characterise posterior corneal surface features in patients with DS and to compare them with healthy and mild keratoconus corneas. This research was retrospective and no...

The Effects of Transcranial Direct Current Stimulation (tDCS) Combined With Proprioceptive Training for Blind Individuals: The Study Protocol for a Randomized Controlled Clinical Trial.

Dec 14, 2020

To maintain the balance, the postural system needs to integrate the three main sensorial systems: visual, vestibular, and somatosensory to keep postural control within the limits of stabilization. Dam...