Researchers did this study to characterise posterior corneal surface features in patients with DS and to compare them with healthy and mild keratoconus corneas.
This research was retrospective and non-randomized. The clinical study included 123 eyes, divided into three groups, and took place at Vissum Alicante. The present study had only patients with no previous ocular surgery, no corneal scars, and no active ocular disease other than keratoconus. Researchers used the Sirius System topographer to analyze posterior corneal surface keratometry, shape and keratoconus screening indices, posterior corneal aberrations, corneal volume, and pachymetry.
Compared to the controls, patients with DS had a steeper and more irregular posterior corneal surface, with higher aberrations and thinnest pachymetry. Researchers found no statistically significant difference between patients with DS and patients with mild keratoconus in KM, HOA, coma-like, and pachymetry.
The study concluded that the posterior corneal surface of patients with DS is steeper, more irregular, and shows more higher-order aberrations and reduced volume, and thinner pachymetry than patients with healthy corneas. Additionally, the posterior corneal surface in patients with DS had identical characteristics to those found in mild keratoconus.
Reference: https://bjo.bmj.com/content/104/12/1683
