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Critical Care General

Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model.

Jul 16, 2020

Given that aminoglycosides, such as amikacin, may be used for multi-drug resistant infections, optimization of therapy is paramount for improved treatment outcomes. This study aims to investigate the...

Impact of breast milk-acquired cytomegalovirus infection in premature infants: Pathogenesis, prevention, and clinical consequences?

Jul 16, 2020

Maternal-fetal transmission of cytomegalovirus (CMV) represents the most common infectious cause of long-term neurodevelopmental disability in children. Congenital CMV (cCMV) infection is associated w...

Treatment of Depression After Traumatic Brain Injury: A Systematic Review Focused on Pharmacological and Neuromodulatory Interventions.

Jul 16, 2020

Depression is the most common psychiatric sequela after traumatic brain injury (TBI) and poses a variety of treatment challenges. There is a lack of clinical trials focused on biological interventions...

A Pilot Study of Brain Injury in Police Officers: A Source of Mental Health Problems?

Jul 16, 2020

Police officers have a high risk of injury through assaults, road traffic incidents and attending domestic calls, with many officers developing post-traumatic stress disorder (PTSD) as a consequence. ...

Complementary and Alternative Medicine Prescribing Practices Among Sports Medicine Providers.

Jul 16, 2020

The drive for a quick return to sport after injury can be great. Athletes look to their sports medicine provider for guidance on a speedy and effective recovery. The sports medicine physician has a nu...

30-day Readmissions and Reoperations after Total Elbow Arthroplasty: A National Database Study.

Jul 16, 2020

The purpose of this study was to determine the rate of short-term complications after TEA and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow tra...

Silent Hypoxia in Patients with SARS CoV-2 Infection before Hospital Discharge.

Jul 16, 2020

To assess the degree of hypoxia and subjective dyspnoea elicited by a 6-minute walking test (6 MWT) in COVID-19 patients prior to discharge.A 6 MWT was performed in 26 discharge-ready COVID-19 pat...

Intensity of Renal Replacement Therapy and Duration of Mechanical Ventilation: Secondary Analysis of the Acute Renal Failure Trial Network Study.

Jul 16, 2020

Randomized clinical trials have failed to show benefit from increasing intensity of renal replacement therapy (RRT) but continue to be frequently used. In addition, intensive RRT is associated with an...

Using Causal Diagrams to Improve the Design and Interpretation of Medical Research.

Jul 16, 2020

Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent ...

A Nitric Oxide-Releasing Hydrogel for Enhancing the Therapeutic Effects of Mesenchymal Stem Cell Therapy for Hindlimb Ischemia.

Jul 16, 2020

Therapeutic angiogenesis with mesenchymal stem cells (MSCs) is promising for the clinical treatment of peripheral artery disease (PAD). However, the heterogeneous proangiogenic nature of MSCs is a key...

The diagnoses and outcomes of emergency patients with an elevated D-dimer over the next 90 days.

Jul 16, 2020

it is not known what diagnoses are associated with an elevated D-dimer in unselected patients attending emergency departments (ED), nor their associated outcomes.prospective observational study of 1,6...

Rationale and design of the RIGHT trial: A multicenter, randomized, double-blind, placebo-controlled trial of anticoagulation prolongation versus no anticoagulation after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.

Jul 16, 2020

Current guidelines recommend anticoagulation therapy during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). However, whether anticoagulation s...

Conference Highlights - AIDS 2020: Virtual - A Focus on COVID-19

Jul 14, 2020

New research was presented at AIDS 2020: Virtual, the 23rd International AIDS Conference, from July 6-10, much of it focused on the intersection of COVID-19 and HIV. The features below highlight some ...

Long-term risk of heart failure and mortality following mitral valve surgery in patients with and without right ventricular pacemaker.

Jul 13, 2020

Patients undergoing mitral valve surgery are at risk of developing postoperative conduction blocks and have a high incidence of heart failure (HF). Mitral valve surgery often results in reduced left v...

Organ care system lung resulted in lower apoptosis and inos expression in donor lungs.

Jul 13, 2020

Ischemia/reperfusion injury after lung transplantation is still today an important complication in up to 25% of patients. The Organ Care System (OCS) Lung, an advanced normothermic ex-vivo lung perfus...

Use of perfusion index to detect hemodynamic changes in endotoxemic pigs.

Jul 13, 2020

The perfusion index (PI) derived from plethysmographic signals provides a noninvasive indication of peripheral perfusion. This study aimed to investigate changes in PI and other hemodynamic variables ...

Clinical characteristics and outcome of SARS-CoV-2 infection in Italian pediatric oncology patients: a study from the Infectious Diseases Working Group of the AIEOP.

Jul 13, 2020

Little is known as yet about the outcome of SARS-CoV-2 infection in children being treated for cancer.We collected information on the clinical characteristics and outcomes of a cohort of 29 children (...

Anxiety and Depression of Nurses in a North West Province in China During the Period of Novel Coronavirus Pneumonia Outbreak.

Jul 13, 2020

To investigate the anxiety and depression levels of frontline clinical nurses working in 14 hospitals in Gansu Province, China, during this period.A cross-sectional survey was conducted online between...

Dementia screening in elderly high-risk patients following heart failure decompensation may predict unfavorable long-term clinical outcomes.

Jul 13, 2020

Recently heart failure (HF) has been found to be a new dementia risk factor, nevertheless their relations in patients following HF decompensation remain unknown. We sought to investigate whether a scr...

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Jul 13, 2020

Mitochondrial reactive oxygen species (ROS) production upon reperfusion of ischemic tissue initiates the ischemia/reperfusion (I/R) injury associated with heart attack. During ischemia, succinate accu...

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