Computed tomography-based vertebral attenuation values (CT-based HU) have been shown to correlate with T-scores on DEXA scan; and have been acknowledged as an independent factor for predicting fragility fractures. Most patients undergoing lumbar surgeries require CT as part of their pre-operative evaluation.
The current study was thus planned to evaluate the role of lumbar CT as an opportunistic investigation in determining BMD pre-operatively in patients undergoing lumbar fusion.
Prospective cohort study PATIENT SAMPLE: : Patients older than 45 years, who underwent one- to two-level lumbar (L3-S1 levels) fusions OUTCOME MEASURES: : Comparison of the quantitative assessment of osteoporosis using Hounsfield Units on CT (L1-L5) and mean lumbar T-scores on DEXA (Dual Energy Xray Absorptiometry) HYPOTHESIS: : HU on CT is comparable to T-score on DEXA as a suitable modality for the assessment of osteoporosis in patients undergoing 1-2 level lumbar fusion METHODS: : A prospective cohort study was conducted between January and December 2021. Patients older than 45 years, who underwent one- to two-level lumbar (L3-S1 levels) fusions and had complete clinico-radiological records, were prospectively enrolled. A comparison was drawn between the HU [measured by placing an oval region of interest (ROI) over axial, sagittal and coronal images of lumbar vertebrae] on CT and T-scores on DEXA, and analyzed statistically. The HU values correlating best with normal (group A), osteopenia (B) and osteoporosis (C) categories (classified based on T-scores of lumbar spines) were determined statistically.
Overall, 87 patients [mean age of 60.56±11.63 years; 63 (72.4%) female patients] were prospectively studied. There was a statistically significant difference in the mean age (p=0.01) and sex distribution (predominantly female patients; p=0.03) of patients belonging to groups B (osteopenic) and C (osteoporotic patients), as compared with group A. The greatest correlation between T-score (on DEXA) and HU (on CT) for differentiating osteopenia (group B) from group A was observed at levels L1 (p<0.001), L2 (p<0.001) and L3 (p<0.001). Based on receiver-operating characteristic (ROC) curve analysis, the cut-off values for HU for identifying osteopenia were 159 (at L1; sensitivity 81.6 and specificity 80) and 162 (at L2; sensitivity 80 and specificity 71.1). In addition, there was statistically significant correlation between T-score (on DEXA) and HU at all the lumbar levels for distinguishing osteoporosis (group C), although the difference was most evident at the upper lumbar (L1 and L2) levels (p<0.001). Based on ROC analysis, cut-off HU values for defining osteoporosis were 127 (at L1; sensitivity 71.3 and specificity 70) and 117 (at L2; sensitivity 65.5 and specificity 90).
Based on our study, the measurement of HU on CT at upper lumbar levels can be considered as “surrogate marker” for BMD in the diagnosis of osteopenia (cut-off: 159 at L1, 162 at L2) and osteoporosis (cut-off: 127 at L1, 117 at L2) in patients undergoing lumbar fusion surgeries. The HU measurements on CT at the lower lumbar levels (L4 and L5) are less reliable in this pre-operative scenario.

Copyright © 2023. Published by Elsevier Inc.