The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure. Aging is the main risk factor for these diseases. Such susceptibility to disease is explained, at least in part, by the increase of oxidative stress, in which it damages cellular components such as proteins, DNA, and lipids. In addition, the chronic inflammatory process in aging “inflammaging” also contributes to cell damage, creating a stressful environment which drives to the development of CVDs. Taken together, it is possible to identify the molecular connection between oxidative stress and the inflammatory process, especially by the crosstalk between the transcription factors Nrf-2 and NF-B which are mediated by redox signalling and are involved in aging. Therapies that control this process are key targets in the prevention/combat of age-related CVDs. In this review, we show the basics of inflammation and oxidative stress, including the crosstalk between them, and the implications on age-related CVDs.Copyright © 2020 Arthur José Pontes Oliveira de Almeida et al.
About The Expert
Arthur José Pontes Oliveira de Almeida
Mathania Silva de Almeida Rezende
Sabine Helena Dantas
Sonaly de Lima Silva
Júlio César Pinheiro Lúcio de Oliveira
Fátima de Lourdes Assunção Araújo de Azevedo
Rayanne Maira Felix Ribeiro Alves
Geovânia Maria Sales de Menezes
Pablo Ferreira Dos Santos
Tays Amanda Felisberto Gonçalves
Valérie B Schini-Kerth
Isac Almeida de Medeiros
References
PubMed