Risk of Suicide in Association with Major Depressive Disorder among Patients with Dementia: A Population-based Nested Case-Control Study.

Sep 23, 2024

Experts: Jiun-Yi Wang,Yi-Ting Hsu,Chih-Yuan Lin,Chien-Hui Liu,Kun-Chia Chang,Chih-Ching Liu

This study aimed to explore the association between major depressive disorder (MDD) and suicide risk in dementia patients.
A cohort of 625,218 individuals aged ≥40 years with dementia between 2007 and 2018 was identified from Taiwan’s National Health Insurance Research Database. After excluding prevalent cases in 2007. Subsequently, a nested case-control study enrolled 1,256 suicide cases and 5,022 matched controls was conducted. The frequencies of MDD-related outpatient or inpatient visits over a 7-year period preceding the event dates were calculated and analyzed for association using conditional logistic regression.
Dementia comorbid with MDD was associated with increased suicide risk (adjusted odds ratio [AOR]: 2.67), particularly in individuals with ≤1.0 MDD episodes per year (AOR: 2.85). Similar association was observed only in individuals aged ≥65 years and males, with a pronounced risk of suicide in those ≤1.0 MDD episodes per year (AOR: 3.08 for individuals aged ≥65 years; AOR: 3.28 for males). Conversely, the risk increase was evident with >1.0 MDD episodes per year in those aged <65 years (AOR: 3.04) and females (AOR: 2.45).
MDD is associated with suicide risk in dementia patients, with the strength of this association possibly varying by age and gender.

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ABOUT THE EXPERTS

Jiun-Yi Wang,Yi-Ting Hsu,Chih-Yuan Lin,Chien-Hui Liu,Kun-Chia Chang,Chih-Ching Liu

Jiun-Yi Wang

Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan. Department of Medical Research, China Medical University Hospital, China Medical University, Taiwan.

Yi-Ting Hsu

Department of Neurology, China Medical University Hospital, Taichung, Taiwan. Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan. College of Medicine, China Medical University, Taichung, Taiwan.

Chih-Yuan Lin

Institute of Health and Welfare Policy, School of Medicine, National Yang Ming Chiao Tung University, Taiwan. Department of Neurology, Taipei City Hospital, Linsen Chinese Medicine Branch, Taipei, Taiwan.

Chien-Hui Liu

Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taiwan. Division of Emergency Medical Service, New Taipei City Fire Department, New Taipei City, Taiwan.

Kun-Chia Chang

Jianan Psychiatric Center, Ministry of Health and Welfare, Taiwan. Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Chih-Ching Liu

Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taiwan. Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City, Taiwan.