The following is the summary of “Ten-year follow-up of lung cancer patients with resected adenocarcinoma in situ or minimally invasive adenocarcinoma: Wedge resection is curative” published in the December 2022  issue of Thoracic and cardiovascular surgery by Deng, et al.

The purpose of this research was to compare the long-term success rates of different forms of surgical resection for adenocarcinoma in situ and minimally invasive adenocarcinoma in patients with lung cancer. There was a retrospective analysis of patients who had resection for lung cancer between December 2007 and December 2012. Researchers enrolled patients diagnosed with either in situ adenocarcinoma or slightly invasive adenocarcinoma on pathology. Second primary lung cancer risk and postoperative survival were studied.

Investigators enrolled 53 patients with adenocarcinoma in situ and 72 individuals with minimally invasive adenocarcinoma after re-evaluating the histological findings of 1,696 patients with lung cancer. Altogether, 125 patients were diagnosed with adenocarcinoma in situ/minimally invasive adenocarcinoma; 86 (60.8%) were female; 114 (91.2%) were never smokers; and the vast majority (78, 62.4% were treated by wedge resection. After surgery, patients were followed for a median of 111 months. Adenocarcinoma in situ and minimally invasive adenocarcinoma both had a recurrence-free survival rate of 100% after 10 years, and a 10-year overall survival rate of 98.1% and 97.2%, respectively. Patients who underwent lobectomy or wedge resection had similar rates of recurrence-freeIn addition, patientsl at 10 years. A total of 63.1% (41/65) of individuals tested by mutational analysis had EGFR mutations.

The likelihood of a second primary lung cancer emerging 10 years after resection was 8.4% for adenocarcinoma in situ and 4.3% for minimally invasive adenocarcinoma (P=.298 and P=.525, respectively). There is no recurrence of pathological adenocarcinoma in situ or minimally invasive adenocarcinoma over the 10-year follow-up period after resection. Wedge resection is the ideal surgical method for nodules in the appropriate position, and it has a high cure rate for these patients.

Source: sciencedirect.com/science/article/abs/pii/S0022522322007139