Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder.

Mar 1, 2021

Contributor: Thomas Wolfers,Jaroslav Rokicki,Dag Alnaes,Pierre Berthet,Ingrid Agartz,Seyed Mostafa Kia,Tobias Kaufmann,Mariam Zabihi,Torgeir Moberget,Ingrid Melle,Christian F Beckmann,Ole A Andreassen,Andre F Marquand,Lars T Westlye

Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder.

Identifying brain processes involved in the risk and development of mental disorders is a major aim. We recently reported substantial interindividual heterogeneity in brain structural aberrations among patients with schizophrenia and bipolar disorder. Estimating the normative range of voxel-based morphometry (VBM) data among healthy individuals using a Gaussian process regression (GPR) enables us to map individual deviations from the healthy range in unseen datasets. Here, we aim to replicate our previous results in two independent samples of patients with schizophrenia (n1 = 94; n2 = 105), bipolar disorder (n1 = 116; n2 = 61), and healthy individuals (n1 = 400; n2 = 312). In line with previous findings with exception of the cerebellum our results revealed robust group level differences between patients and healthy individuals, yet only a small proportion of patients with schizophrenia or bipolar disorder exhibited extreme negative deviations from normality in the same brain regions. These direct replications support that group level-differences in brain structure disguise considerable individual differences in brain aberrations, with important implications for the interpretation and generalization of group-level brain imaging findings to the individual with a mental disorder.
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

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About The Expert

Thomas Wolfers

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, The Netherlands.

Jaroslav Rokicki

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Dag Alnaes

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Pierre Berthet

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Ingrid Agartz

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.

Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.

Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden.

Seyed Mostafa Kia

Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, The Netherlands.

Tobias Kaufmann

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Mariam Zabihi

Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, The Netherlands.

Torgeir Moberget

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Ingrid Melle

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

Christian F Beckmann

Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, The Netherlands.

Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

Ole A Andreassen

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.

Andre F Marquand

Donders Center for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behavior, Radboud University, Nijmegen, The Netherlands.

Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.

Department of Neuroimaging, Center for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, UK.

Lars T Westlye

Department of Psychology, University of Oslo, Oslo, Norway.

Division of Mental Health and Addiction, Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo and Oslo University Hospital, Oslo, Norway.

KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.

References

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