It has been found that in advanced glaucoma, the sensitivity of the central 10-degree visual field (VF) is substantially correlated with both the density of superficial vessels in the macula and the thickness of the ganglion cell complex (GCC). In eyes with advanced open-angle glaucoma, researchers aimed to determine if there was a correlation between macular vessel density (MVD) as measured by optical coherence tomography angiography (OCTA) and sensitivity to visual fields (VFs) at 10-2. Analysis of 44 patients’ macular OCTA and sensitivity to 10-2 VF was performed [mean deviation (MD) <−10 dB]. The mean sensitivity (MS) of VFs at the regional and global levels was determined using total deviation plots. Using 2 sectoral definitions, OCTA scans of 3×3 mm2 and 6×6 mm2 were used to acquire superficial and deep MVD, respectively. The MVD measurements and the macular GCC thickness were acquired simultaneously from the same scan using spectral-domain optical coherence tomography. For this purpose, we employed linear regression models for analysis (R2). When comparing the 2 maps, the 1 with the lower MS had less MVD and GCC on the surface in each region, regardless of the scan size. Individual picture sectors showed weaker associations than the Early Treatment Diabetic Retinopathy Study map. It was found that MVD in the deep layers was not linked to central MS. GCC correlations were stronger than MVD associations in the central 5-degree MS, although 66 mm2 and perifoveal vascular density showed better associations with central 10-degree MS than GCC thickness (eg, R2 from 25.7 to 48.1 µm and 7.8% to 32.5%, respectively).MVD and GCC complement metrics in eyes with advanced glaucoma because of the stronger MVD-central 10-degree VF relationship compared with GCC and the stronger GCC-central 5-degree VF association compared with MVD. A longitudinal study is essential to compare the value of the GCC and MVD over time.
