Here are what the editors at HealthDay consider to be the most important developments in Neurology for October 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Cognitive Ability in Childhood Linked to Cognitive Scores at 70
THURSDAY, Oct. 31, 2019 (HealthDay News) — Childhood cognitive ability is associated with cognitive scores, including the Preclinical Alzheimer Cognitive Composite (PACC), more than 60 years later, according to a study published online Oct. 30 in Neurology.
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Fetal Exposure to Acetaminophen May Increase Risk for ADHD, ASD
WEDNESDAY, Oct. 30, 2019 (HealthDay News) — Cord biomarkers of fetal exposure to acetaminophen are associated with an increased risk for childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), according to a study published online Oct. 30 in JAMA Psychiatry.
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CDC: U.S. Life Expectancy Up Slightly, Mortality Lower in 2017
WEDNESDAY, Oct. 30, 2019 (HealthDay News) — Life expectancy has increased slightly in the United States, and mortality is lower than in 2007, according to a report published Oct. 30 by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.
Facebook Launches Preventive Health Tool
TUESDAY, Oct. 29, 2019 (HealthDay News) — A new tool designed to help guide preventive care for heart disease, cancer, and seasonal flu was launched in the United States Monday by Facebook.
Aspirin May Slow Growth of Multiple Intracranial Aneurysms
TUESDAY, Oct. 29, 2019 (HealthDay News) — Aspirin is associated with a reduced rate of aneurysm growth for patients with multiple intracranial aneurysms, according to a review published online Oct. 29 in the Journal of Neurosurgery.
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Evidence for Use of Cannabinoids to Treat Mental Disorders Lacking
TUESDAY, Oct. 29, 2019 (HealthDay News) — There is little evidence to suggest that cannabinoids improve mental disorders, according to a review published online Oct. 28 in The Lancet Psychiatry.
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Patients Should Restart Blood Thinners After GI Bleed
TUESDAY, Oct. 29, 2019 (HealthDay News) — Patients who restart their blood thinners after a gastrointestinal bleed have a lower risk for dying within the next two years even though they have a higher risk for recurrent gastrointestinal bleeding, according to a study recently published in Alimentary Pharmacology and Therapeutics.
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CV Risk Score Tied to Subclinical Cerebrovascular Disease on MRI
TUESDAY, Oct. 29, 2019 (HealthDay News) — Simple cardiovascular risk scores are associated with the presence of imaging-detected subclinical cerebrovascular disease, according to a study published online Sept. 30 in the European Heart Journal: Cardiovascular Imaging.
Prevalence of Pain Higher in Children With Autism
MONDAY, Oct. 28, 2019 (HealthDay News) — Children with autism spectrum disorder (ASD) have an elevated prevalence of pain compared with children without ASD, according to a research letter published online Oct. 28 in JAMA Pediatrics.
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Outcomes Poor With Medical Care From Fraud, Abuse Perpetrators
MONDAY, Oct. 28, 2019 (HealthDay News) — Receiving medical care from fraud and abuse perpetrators (FAPs), subsequently excluded from Medicare, is associated with higher rates of all-cause mortality and emergency hospitalization, according to a study published online Oct. 28 in JAMA Internal Medicine.
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Spironolactone Noninferior in Duchenne Muscular Dystrophy
MONDAY, Oct. 28, 2019 (HealthDay News) — In a head-to-head study of mineralocorticoid receptor antagonists, spironolactone was found to be noninferior to eplerenone for slowing the progression of heart damage in boys with Duchenne muscular dystrophy (DMD), according to a study published in the Oct. 1 issue of the Journal of the American Heart Association.
No Link Found Between Teen Contact Sports, Later Mental Health Issues
FRIDAY, Oct. 25, 2019 (HealthDay News) — Adolescents who play contact sports, including football, are not at increased risk for subsequent cognitive impairment, depression, or suicidal thoughts in early adulthood, according to a study published online Sept. 26 in the Orthopaedic Journal of Sports Medicine.
Early-Stage Alzheimer Disease Has Adverse Financial Consequences
FRIDAY, Oct. 25, 2019 (HealthDay News) — Early-stage Alzheimer disease seems to put households at risk for large adverse changes in liquid assets and may reduce net wealth, according to a study published online Oct. 25 in Health Economics.
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Google Searches for CBD Up Substantially
THURSDAY, Oct. 24, 2019 (HealthDay News) — Interest in cannabidiol (CBD) across the United States has increased considerably and is accelerating, according to a research letter published online Oct. 23 in JAMA Network Open.
Regional Brain Atrophy ID’d in Patients With History of TBI
THURSDAY, Oct. 24, 2019 (HealthDay News) — Individuals with a history of traumatic brain injury (TBI) have regional brain atrophy, especially in the ventral diencephalon, putamen, and pallidum, according to a study recently published in the Journal of Alzheimer’s Disease.
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Serum Elaidic Acid Levels Tied to Dementia, Alzheimer Disease
WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Higher serum levels of elaidic acid, an objective biomarker for industrial trans fat, are associated with an increased risk for developing all-cause dementia and Alzheimer disease, according to a study published online Oct. 23 in Neurology.
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Neurodegenerative Disease Deaths Up in Former Soccer Players
WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Former soccer players have an increased risk for mortality from neurodegenerative diseases, according to a study published online Oct. 21 in the New England Journal of Medicine.
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Effect of Fluoxetine on Repetitive Behaviors in ASD Youth Unclear
WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Treatment with fluoxetine appears to result in significantly lower scores for obsessive compulsive behaviors at 16 weeks among children and adolescents with autism spectrum disorder (ASD), but interpretation of the data is limited, according to a study published in the Oct. 22/29 issue of the Journal of the American Medical Association.
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Prophylactic Melatonin Does Not Cut Delirium After Major Cardiac Surgery
WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Prophylactic use of melatonin does not prevent delirium after major cardiac surgery, according to a study published online Oct. 8 in the Journal of the American Geriatrics Society.
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New Alzheimer Disease Drug to Be Submitted for FDA Approval
TUESDAY, Oct. 22, 2019 (HealthDay News) — A new drug to treat early Alzheimer disease will be submitted to the U.S. Food and Drug Administration for approval, maker Biogen Inc. said Tuesday.
AP News Article
Biogen Press Release
More Choices, Lower Premiums for ACA Consumers Next Year
TUESDAY, Oct. 22, 2019 (HealthDay News) — There will be more health insurance choices and a slight decrease in premiums for many consumers next year under the Affordable Care Act, according to the Trump administration.
Deep Learning Algorithm Uses CT to ID Intracranial Hemorrhages
TUESDAY, Oct. 22, 2019 (HealthDay News) — A deep learning algorithm has accuracy comparable to that of radiologists for the diagnosis of acute intracranial hemorrhage on head computed tomography (CT), according to a study published online Oct. 21 in the Proceedings of the National Academy of Sciences.
Antiviral Antibodies ID’d in CSF of Acute Flaccid Myelitis Cases
MONDAY, Oct. 21, 2019 (HealthDay News) — Enterovirus (EV)-specific antibodies have been identified in the cerebrospinal fluid (CSF) of pediatric cases of acute flaccid myelitis (AFM) versus controls, according to a study published online Oct. 21 in Nature Medicine.
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Long Sleep Duration Linked to Cognitive Decline in Hispanics
MONDAY, Oct. 21, 2019 (HealthDay News) — Long sleep duration predicts seven-year cognitive decline among U.S. Hispanic/Latino patients, according to a study published online Oct. 9 in Alzheimer’s & Dementia.
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Exercise Intolerance May Harm Neurocognition in ALL Survivors
MONDAY, Oct. 21, 2019 (HealthDay News) — For adult survivors of childhood acute lymphoblastic leukemia (ALL), exercise intolerance is associated with worse neurocognitive outcomes, according to a study published online Oct. 21 in Cancer.
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Tranexamic Acid Within Three Hours Cuts Some TBI Deaths
MONDAY, Oct. 21, 2019 (HealthDay News) — Among patients with mild-to-moderate acute traumatic brain injury (TBI), the risk for head injury-related death is reduced in those receiving tranexamic acid within three hours compared with placebo, according to a study published online Oct. 14 in The Lancet.
Extended Estrogen Therapy Aids Late-Life Cognition
FRIDAY, Oct. 18, 2019 (HealthDay News) — Longer use of estrogen hormone therapy is associated with higher cognitive status in late life, according to a study published online Oct. 14 in Menopause.
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Exposure to Secondhand Smoke Linked to Choroidal Thinning in Children
FRIDAY, Oct. 18, 2019 (HealthDay News) — Exposure to secondhand smoking is associated with choroidal thinning among children aged 6 to 8 years, according to a study published online Oct. 17 in JAMA Ophthalmology.
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Outcomes Poorer for Extreme Preemies Transferred After Birth
THURSDAY, Oct. 17, 2019 (HealthDay News) — Birth in a nontertiary hospital and transfer within 48 hours is associated with poorer outcomes compared with birth in a tertiary hospital for extremely preterm infants, according to a study published online Oct. 16 in The BMJ.
PTSD Linked to Early Incident TIA, Stroke in Young Veterans
THURSDAY, Oct. 17, 2019 (HealthDay News) — For young and middle-aged veterans, posttraumatic stress disorder (PTSD) is associated with an increased risk for early incident transient ischemic attack (TIA) and ischemic stroke, according to a study published online Oct. 17 in Stroke.
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Risk, Severity of CTE Increase With Years of Football Played
THURSDAY, Oct. 17, 2019 (HealthDay News) — The risk and severity of chronic traumatic encephalopathy (CTE) increase with the number of years playing American football, according to a study published online Oct. 7 in the Annals of Neurology.
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Brain Recovery After Concussion Lags Symptom Resolution
WEDNESDAY, Oct. 16, 2019 (HealthDay News) — Complete concussion recovery may be more complex and take longer than previously thought, according to a study published online Oct. 16 in Neurology.
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Dopamine Agonists Tied to Higher Risk for Psychiatric Events
WEDNESDAY, Oct. 16, 2019 (HealthDay News) — Patients with primary restless leg syndrome who begin dopamine agonist (DA) therapy may be at increased risk for adverse psychiatric events, according to a study published in the September issue of the Journal of Clinical Sleep Medicine.
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Decrease Seen in Football Practice-Related Concussions
TUESDAY, Oct. 15, 2019 (HealthDay News) — Rates of concussion during football practice and recurrent concussion rates across all high school sports decreased from the 2013-2014 to 2017-2018 school years, according to a study published online Oct. 15 in Pediatrics.
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Nonpharmacologic Interventions Reduce Agitation in Dementia
TUESDAY, Oct. 15, 2019 (HealthDay News) — For adults with dementia, nonpharmacologic interventions seem to be more efficacious than pharmacologic interventions for reducing aggression and agitation, according to a review and meta-analysis published online Oct. 15 in the Annals of Internal Medicine.
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Children With Autism Found to Have Higher Risk for Obesity
TUESDAY, Oct. 15, 2019 (HealthDay News) — Autism spectrum disorders (ASDs) appear to increase the risk for childhood obesity, according to a review published online Oct. 8 in Obesity Reviews.
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Gastric Bypass Linked to Lower Risk for Major Birth Defects
TUESDAY, Oct. 15, 2019 (HealthDay News) — Infants born to women who have undergone Roux-en-Y gastric bypass surgery have a lower risk for major birth defects than those born to matched control women, according to a study published in the Oct. 15 issue of the Journal of the American Medical Association.
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Bipolar Disorder May Increase Risk for Developing Parkinson Disease
TUESDAY, Oct. 15, 2019 (HealthDay News) — Patients with bipolar disorder (BD) seem to have an increased risk for developing Parkinson disease (PD), according to a review published online Oct. 14 in JAMA Neurology.
Retinal Nerve Fiber Loss Linked to Disability in Multiple Sclerosis
FRIDAY, Oct. 11, 2019 (HealthDay News) — Reduction in peripapillary retinal nerve fiber layer (pRNFL) thickness is significantly associated with physical and cognitive disability in patients with multiple sclerosis (MS), according to a study published in the November issue of Multiple Sclerosis and Related Disorders.
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Poor Glycemic Control May Up Risk for Stroke, Death in T2DM
FRIDAY, Oct. 11, 2019 (HealthDay News) — Poor glycemic control is associated with increased risks for stroke and death among patients with type 2 diabetes, according to a study published online Oct. 1 in Diabetes, Obesity and Metabolism.
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Effects on Quality of Life Mixed for Tx of Multiple Myeloma
FRIDAY, Oct. 11, 2019 (HealthDay News) — Most dimensions of quality of life (QoL) are impaired in patients with relapsed/refractory multiple myeloma, and treatment may have mixed effects on QoL, according to a study published online Sept. 26 in Leukemia & Lymphoma.
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Patient Portal Use Has Positive Impact on Preventive Health Behaviors
FRIDAY, Oct. 11, 2019 (HealthDay News) — Patient portal use has a positive impact on preventive health behaviors, but not on chronic health outcomes, according to a study published in the October issue of the Journal of Medical Internet Research.
Predictors of Work Disability ID’d in Multiple Sclerosis Patients
THURSDAY, Oct. 10, 2019 (HealthDay News) — Physical disability, depressive symptoms, and reduced information processing affect work-related disability and vocational status among patients with multiple sclerosis, according to a study published in the November issue of Multiple Sclerosis and Related Disorders.
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Odds of Autism Up in Children With Congenital Heart Disease
THURSDAY, Oct. 11, 2019 (HealthDay News) — The odds of developing autism spectrum disorder (AuSD) are increased for children with congenital heart disease (CHD), according to a study published online Oct. 10 in Pediatrics.
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Rate of Advancement of Feeding Volume Does Not Impact Survival
THURSDAY, Oct. 10, 2019 (HealthDay News) — For very preterm or very low-birth-weight infants, advancing feeding volume in faster increments versus slower increments is not associated with a difference in survival without moderate or severe neurodevelopmental disability at 24 months, according to a study published in the Oct. 10 issue of the New England Journal of Medicine.
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Sex-Specific Criteria May Up Accuracy for Diagnosis of aMCI
THURSDAY, Oct. 10, 2019 (HealthDay News) — There seems to be a 20 percent diagnostic error rate with use of non-sex-specific amnestic mild cognitive impairment (aMCI) diagnostic criteria, according to a study published online Oct. 9 in Neurology.
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Medicare Fraud-Prevention Rules to Be Revised
WEDNESDAY, Oct. 9, 2019 (HealthDay News) — Revision of decades-old Medicare rules meant to prevent fraud has been proposed by the Trump administration.
2000 to 2015 Saw Increase in Medicare GME Payments
WEDNESDAY, Oct. 9, 2019 (HealthDay News) — Medicare graduate medical education (GME) payments increased significantly from 2000 to 2015, according to a study published online Oct. 7 in JAMA Internal Medicine.
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Review: E-Stim Devices May Increase Spinal Fusion Rates
WEDNESDAY, Oct. 9, 2019 (HealthDay News) — Electrical stimulation technologies (ESTs) appear to be effective for increasing spinal fusion, according to a review of preclinical and clinical literature published online Oct. 8 in the Journal of Neurosurgery: Spine.
Burnout Linked to Poor Quality Care in Published Literature
TUESDAY, Oct. 8, 2019 (HealthDay News) — In the published literature, burnout in health care professionals is frequently associated with poor-quality care, but the effect size may be smaller than reported, according to data from a systematic review published online Oct. 8 in the Annals of Internal Medicine.
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Cost of Waste in U.S. Health System Estimated
TUESDAY, Oct. 8, 2019 (HealthDay News) — The estimated cost of waste in the U.S. health care system varies from $760 to $935 billion, according to a special communication published online Oct. 7 in the Journal of the American Medical Association.
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Dog Ownership May Lower Risk for Death After Major CV Event
TUESDAY, Oct. 8, 2019 (HealthDay News) — Dog ownership is associated with better outcomes after a major cardiovascular event as well as a reduced risk for all-cause mortality, according to a cohort study and a meta-analysis published online Oct. 8 in Circulation: Cardiovascular Quality and Outcomes.
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Data Suggest Viral Etiology for Pediatric Acute Flaccid Myelitis
MONDAY, Oct. 7, 2019 (HealthDay News) — Surveillance data for acute flaccid myelitis (AFM) suggests a viral etiology, according to a study published online Oct. 7 in Pediatrics.
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With Comorbidities, Less Than Six Hours of Sleep Ups Risk for Early Death
FRIDAY, Oct. 4, 2019 (HealthDay News) — Middle-aged adults with high blood pressure, type 2 diabetes, heart disease, or stroke could be at higher risk for cancer and early death when sleeping less than six hours per day, according to a study published online Oct. 2 in the Journal of the American Heart Association.
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Hyperemesis Gravidarum Linked to Autism Spectrum Disorder
THURSDAY, Oct. 3, 2019 (HealthDay News) — Hyperemesis gravidarum (HG) is associated with a higher risk for autism spectrum disorder (ASD), according to a study published online Oct. 3 in the American Journal of Perinatology.
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Universal Screening for Autism Feasible in Pediatric Network
THURSDAY, Oct. 3, 2019 (HealthDay News) — Universal screening for autism spectrum disorder (ASD) is feasible in a pediatric primary care network, according to a study published online Sept. 27 in Pediatrics.
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Risk Calculator Can Help Predict Postmenopausal Morbidity
THURSDAY, Oct. 3, 2019 (HealthDay News) — A new risk prediction calculator can make health risk predictions for several outcomes simultaneously in postmenopausal women, according to a study published online Sept. 16 in Menopause.
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Early Adult Income Volatility Tied to Later Brain Health
WEDNESDAY, Oct. 2, 2019 (HealthDay News) — Income volatility during a 20-year period beginning in young adulthood is associated with worse cognitive function and brain integrity in midlife, according to a study published online Oct. 2 in Neurology.
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Youngest in Classroom at Higher Risk for Diagnosis of Depression
WEDNESDAY, Oct. 2, 2019 (HealthDay News) — Children who are younger compared with their school peers have an increased risk for diagnosis of attention-deficit/hyperactivity disorder (ADHD), intellectual disability, and depression in childhood, according to a study published online Sept. 23 in JAMA Pediatrics.
Decrease in Stroke Incidence Continued Through 2017 in ARIC
TUESDAY, Oct. 1, 2019 (HealthDay News) — In the Atherosclerosis Risk in Communities (ARIC) study, the decrease in stroke rates reported for 1987 to 2011 extended to 2017, according to a study published online Sept. 30 in JAMA Neurology.
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