Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.

Jan 30, 2023

Experts: Zhenghao Li,Kefu Chen,Qi Shao,Hongtao Lu,Xin Zhang,Yingyan Pu,Xuejun Sun,Hua He,Li Cao

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Anxiety and depression are the most common psychiatric comorbidities of MS, which seriously affect patients’ quality of life, treatment compliance, and prognosis. However, current treatments for anxiety and depression in MS show low therapeutic efficacy and significant side effects. In the present study, we explored the therapeutic effects of a novel low-toxic anti-inflammatory drug, nanoparticulate magnesium hydride (MgH), on mood disorders of MS. We observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH treatment. In addition, disease severity and inflammatory demyelination were also diminished. Furthermore, we confirmed the suppressive effect of MgH on depression in the acute restraint stress model. Mechanistically, MgH may play a therapeutic role by promoting microglial M2 polarization, inhibiting microglial M1 polarization, and reducing oxidative stress and mitochondrial damage. Therefore, nanoparticulate MgH may be a promising therapeutic drug for psychiatric comorbidities of MS.
© 2023. The Author(s).

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ABOUT THE EXPERTS

Zhenghao Li,Kefu Chen,Qi Shao,Hongtao Lu,Xin Zhang,Yingyan Pu,Xuejun Sun,Hua He,Li Cao

Zhenghao Li

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.

Kefu Chen

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.

Qi Shao

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.

Hongtao Lu

Department of Naval Medicine, Naval Medical University, Shanghai, 200433, China.

Xin Zhang

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.

Yingyan Pu

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.

Xuejun Sun

Department of Naval Medicine, Naval Medical University, Shanghai, 200433, China.

Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200030, China.

Hua He

Department of Neurosurgery, Third Affiliated Hospital, Naval Medical University, Shanghai, 200438, China. hehua1624@smmu.edu.cn.

Li Cao

Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China. caoli@smmu.edu.cn.