We examined the association of the coronary thrombus microbiota and relative metabolites with major adverse cardiovascular events (MACE) in hyperglycemic patients with ST segment elevation myocardial infarction (STEMI).
Hyperglycemia during STEMI may affect both development and progression of coronary thrombus via gut and thrombus microbiota modifications.
We undertook an observational cohort study of 146 first STEMI patients treated with primary percutaneous coronary intervention (PPCI) and thrombus-aspiration (TA). Patients were clustered, based on admission blood glucose levels, in hyperglycemic (≥140 mg/dl) and normoglycemic (<140 mg/dl). We analyzed gut and thrombus microbiota in all patients. Moreover, we assessed TMAO, CD40L and von Willebrand Factor (vWF) in coronary thrombi. Cox regressions were used for the association between Prevotellaspp. and TMAO terziles and MACE. MACE endpoint at 1 year included death, re-infarction, unstable angina.
In fecal and thrombus samples, we observed a significantly different prevalence of both Prevotellaspp.and Alistipesspp. between patients with hyperglycemia (n=56) and those with normal glucose levels (n=90). The abundance of Prevotella increased in hyperglycemic vs normoglycemic patients whereas the contrary was observed for Alistipes. Interestingly, in coronary thrombus, the content of Prevotella was associated with admission blood glucose levels (p<0.01), thrombus dimensions (p<0.01), TMAO, CDL40 (p<0.01) and vWF (p<0.01) coronary thrombus contents. Multivariate Cox-analysis disclosed a reduced survival in patients with high levels of Prevotella and TMAO in coronary thrombus as compared to patients with low levels of Prevotella and TMAO, after 1-year follow up.
Hyperglycemia during STEMI may increase coronary thrombus burden via gut and thrombus microbiota dysbiosis characterized by an increase of Prevotella and TMAO content in thrombi.
NCT03439592. September 30, 2016 Ethic Committee Vanvitelli University: 268/2016.
Copyright © 2021 Elsevier B.V. All rights reserved.
About The Expert
Celestino Sardu
Maria Consiglia Trotta
Biagio Santella
Nunzia D’Onofrio
Michelangela Barbieri
Maria Rosaria Rizzo
Ferdinando Carlo Sasso
Lucia Scisciola
Fabrizio Turriziani
Michele Torella
Michele Portoghese
Francesco Loreni
Simone Mureddu
Maria Antonietta Lepore
Massimiliano Galdiero
Gianluigi Franci
Veronica Folliero
Arianna Petrillo
Lara Boatti
Fabio Minicucci
Ciro Mauro
Paolo Calabrò
Marisa De Feo
Maria Luisa Balestrieri
Danilo Ercolini
Michele D’Amico
Giuseppe Paolisso
Marilena Galdiero
Raffaele Marfella
References
PubMed