Medical prevention and treatment of radiation-induced carotid injury.

Aug 31, 2020

Contributor: Zhuangzhuang Zheng,Qin Zhao,Jinlong Wei,Bin Wang,Huanhuan Wang,Lingbin Meng,Ying Xin,Xin Jiang

Medical prevention and treatment of radiation-induced carotid injury.

Radiotherapy has significantly improved the survival of cancer patients but is also associated with several adversities, including radiation-induced carotid injury (RICI). The RICI mechanisms are complex, including vessel inflammatory injury, carotid atherosclerosis, intimal proliferation, media necrosis, and peri-adventitial fibrosis. The main manifestation and adverse consequence of RICI is carotid artery stenosis (CAS), which can lead to stroke and transient ischemic attack. Currently, carotid artery injury is primarily diagnosed via color-coded duplex sonography. Early detection of traumatic changes in the carotid artery depends on measurements of carotid intima-media thickness; serum biomarker testing also shows great potential. CAS is mainly treated with carotid endarterectomy or carotid angioplasty and stent implantation. Notably, bone marrow mesenchymal stem cells are advantageous in RICI treatment and reduce carotid inflammation, oxidative stress, and delaying atherosclerosis. This review summarizes the mechanisms, examination methods, and latest treatments for RICI to provide data for its clinical prevention and treatment.
Copyright © 2020. Published by Elsevier Masson SAS.

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About The Expert

Zhuangzhuang Zheng

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: zhengzz2715@mails.jlu.edu.cn.

Qin Zhao

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: jluzhaoqin09@jlu.edu.cn.

Jinlong Wei

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: weijl17@mails.jlu.edu.cn.

Bin Wang

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: wangbin18@mails.jlu.edu.cn.

Huanhuan Wang

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: wanghh2714@mails.jlu.edu.cn.

Lingbin Meng

Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, FL, 33612, USA. Electronic address: lingbin.meng@moffitt.org.

Ying Xin

Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China. Electronic address: xiny@jlu.edu.cn.

Xin Jiang

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China; Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address: jiangx@jlu.edu.cn.

References

PubMed