The study was done to assess 3-year safety and efficacy of EF I-CXL in patients with progressive keratoconus.
This prospective interventional pilot study included 24 eyes of 20 patients, with a mean age of 23.9 years (range: 15 to 36 years). Iontophoresis with riboflavin solution was used for stromal imbibition. The treatment energy was optimized at 30% (7 J/cm2) and ultraviolet-A power set at 18 mW/cm2 × 6.28 minutes of pulsed-light on-off exposure, with a total irradiation time of 12.56 minutes.UDVA, CDVA, corneal tomography, and corneal OCT at baseline and 1, 3, 6, 12, 24, and 3 years postoperatively were evaluated.
At 3 years, average UDVA decreased from 0.50 ± 0.10 to 0.36 ± 0.08 logMAR (P < .05), average maximum keratometry decreased from 52.94 ± 1.34 to 51.4 ± 1.49 diopters (D) (Delta: −1.40 ± 0.80 D; P < .05), average coma improved from 0.24 ± 0.05 to 0.12 ± 0.02 µm (P = .001), and symmetry index decreased from 4.22 ± 1.01 to 3.53 ± 0.90 D. Corneal OCT showed demarcation line detection at 285.8 ± 20.2 µm average depth in more than 80% at 1 month postoperatively.
The study concluded that there were satisfactory I-CXL functional outcomes, increasing the visibility and the depth of the demarcation line closer to epithelium-off standard CXL.
Reference: https://doi.org/10.3928/1081597X-20200406-02
