Individual multidisciplinary clinical phenotypes of nasal and ocular symptoms in hay fever: Crowdsourced cross-sectional study using AllerSearch.

Feb 06, 2023

Experts: Takenori Inomata,Jaemyoung Sung,Kenta Fujio,Masahiro Nakamura,Yasutsugu Akasaki,Ken Nagino,Yuichi Okumura,Masao Iwagami,Keiichi Fujimoto,Nobuyuki Ebihara,Masahiro Nakamura,Akie Midorikawa-Inomata,Hurramhon Shokirova,Tianxiang Huang,Kunihiko Hirosawa,Maria Miura,Mizu Ohno,Yuki Morooka,Nanami Iwata,Yuma Iwasaki,Akira Murakami

Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed to identify the characteristics of nasal and ocular symptoms of hay fever, using the AllerSearch smartphone application.
This mobile health-based prospective observational study using the AllerSearch smartphone application was conducted between February 1, 2018, and May 1, 2020. Individuals who downloaded AllerSearch from Japan and provided comprehensive self-assessments (including 17 items related to quality of life [QoL]-related items) were included. The characteristics and risk factors for allergic rhinitis (AR) and allergic conjunctivitis (AC) were identified using hierarchical heat maps and multivariate logistic regression.
Of the 9041 participants with hay fever, 58.8% had AR and AC, 22.2% had AR, and 5.7% had AC. The AR-AC comorbid cohort showed worse symptoms of hay fever and QoL scores than the other cohorts. Factors (odds ratio, 95% confidence interval) associated with AR-AC included a lower age (0.98, 0.97-0.98), female sex (1.31, 1.19-1.45), liver disease (1.58, 1.26-2.35), dry eye disease (1.45, 1.30-1.63), unknown dry eye disease status (1.46, 1.31-1.62), contact lens use discontinuation during the hay fever season (1.69, 1.28-2.23), and bedroom flooring material other than hardwood, carpet, tatami, or vinyl (1.91, 1.16-3.14).
Analysis of medical big data for hay fever performed using a mobile health app helped identify risk factors and characteristics of AC, AR, and AR-AC. Phenotyping of highly variable symptoms of hay fever, such as nasal and ocular symptoms, can facilitate better-quality clinical care.

Copyright © 2023 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.

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ABOUT THE EXPERTS

Takenori Inomata,Jaemyoung Sung,Kenta Fujio,Masahiro Nakamura,Yasutsugu Akasaki,Ken Nagino,Yuichi Okumura,Masao Iwagami,Keiichi Fujimoto,Nobuyuki Ebihara,Masahiro Nakamura,Akie Midorikawa-Inomata,Hurramhon Shokirova,Tianxiang Huang,Kunihiko Hirosawa,Maria Miura,Mizu Ohno,Yuki Morooka,Nanami Iwata,Yuma Iwasaki,Akira Murakami

Takenori Inomata

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan; AI Incubation Farm, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: tinoma@juntendo.ac.jp.

Jaemyoung Sung

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Kenta Fujio

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Masahiro Nakamura

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Precision Health, Department of Bioengineering, Graduate School of Bioengineering, The University of Tokyo, Tokyo, Japan.

Yasutsugu Akasaki

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Ken Nagino

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Yuichi Okumura

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Masao Iwagami

Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Keiichi Fujimoto

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Nobuyuki Ebihara

Department of Ophthalmology, Urayasu Hospital, Juntendo University, Chiba, Japan.

Masahiro Nakamura

Department of Otorhinolaryngology and Head and Neck Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.

Akie Midorikawa-Inomata

Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Hurramhon Shokirova

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Tianxiang Huang

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Kunihiko Hirosawa

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Maria Miura

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Mizu Ohno

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Yuki Morooka

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Nanami Iwata

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Yuma Iwasaki

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Akira Murakami

Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.