In Situ Forming of Nitric Oxide and Electric Stimulus for Nerve Therapy by Wireless Chargeable Gold Yarn-Dynamos.

Oct 23, 2023

Experts: Min-Ren Chiang,Ya-Hui Lin,Wei-Jie Zhao,Hsiu-Ching Liu,Ru-Siou Hsu,Tsu-Chin Chou,Tsai-Te Lu,I-Chi Lee,Lun-De Liao,Shih-Hwa Chiou,Li-An Chu,Shang-Hsiu Hu

Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO’s short half-life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on-demand high-frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S-nitrosoglutathione), pGSNO)-conjugated on a gold yarn-dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses’ differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo.
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

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ABOUT THE EXPERTS

Min-Ren Chiang,Ya-Hui Lin,Wei-Jie Zhao,Hsiu-Ching Liu,Ru-Siou Hsu,Tsu-Chin Chou,Tsai-Te Lu,I-Chi Lee,Lun-De Liao,Shih-Hwa Chiou,Li-An Chu,Shang-Hsiu Hu

Min-Ren Chiang

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Ya-Hui Lin

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Brain Research Center, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Wei-Jie Zhao

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Hsiu-Ching Liu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Ru-Siou Hsu

Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.

Tsu-Chin Chou

Institute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Tsai-Te Lu

Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Department of Chemistry, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Department of Chemistry, Chung Yuan Christian University, Taoyuan, 320314, Taiwan.

I-Chi Lee

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Lun-De Liao

Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County, 35053, Taiwan.

Shih-Hwa Chiou

Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.

Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.

Li-An Chu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Brain Research Center, National Tsing Hua University, Hsinchu, 300044, Taiwan.

Shang-Hsiu Hu

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.