The objective of PHASE-MX registry is to validate the efficacy and safety of the pharmacoinvasive strategy in comparison with percutaneous coronary intervention (PCI) in patients with acute myocardial infarction with ST segment elevation (STEMI) in a metropolitan region of Mexico. The primary outcome will consist of the composite of cardiovascular death, re-infarction, stroke and cardiogenic shock.
The PHASE-MX registry will include a prospective cohort of patients with STEMI who received reperfusion treatment (mechanical of pharmacological) in the first 12 h after the onset of symptoms. The registry is designed to compare the efficacy and safety of primary PCI and pharmacoinvasive strategy. The simple size was calculated in 344 patients divided into two groups, with an estimated loss rate of 10%. Patients included in the PHASE-MX cohort will be followed for up to one year.
In Mexico, only 5 out of 10 patients with STEMI have access to reperfusion therapy. Pharmacoinvasive strategy is takes advantage of the accessibility of fibrinolysis and the effectiveness of PCI. The present research protocol aims to provide information that serves as a link between information derived from controlled clinical trials and records derived from real world experience.
Copyright: © 2020 Permanyer.
About The Expert
Luis A Baeza-Herrera
Diego Araiza-Garaygordobil
Rodrigo Gopar-Nieto
Grecia I Raymundo-Martínez
Arnoldo Loáisiga-Sáenz
Abraham Villalobos-Flores
Manuel Martínez-Ramos
Laura V Torres-Araujo
Ricardo Pohls-Vázquez
Abraham Luna-Herbert
Arturo Alonso-Vázquez
Itzel V Delgado-Cruz
Alejandro Cabello-López
Pablo Martínez-Amezcua
María A Arias-Mendoza
References
PubMed