Evaluating patient-reported outcome measures (PROMs) for future clinical trials in adult patients with optic neuritis.

Mar 20, 2023

Experts: Jesse Panthagani,Charles O'Donovan,Olalekan Lee Aiyegbusi,Xiaoxuan Liu,Susan Bayliss,Melanie Calvert,Konrad Pesudovs,Alastair K Denniston,David J Moore,Tasanee Braithwaite

To search for and critically appraise the psychometric quality of patient-reported outcome measures (PROMs) developed or validated in optic neuritis, in order to support high-quality research and care.
We systematically searched MEDLINE(Ovid), Embase(Ovid), PsycINFO(Ovid) and CINAHLPlus(EBSCO), and additional grey literature to November 2021, to identify PROM development or validation studies applicable to optic neuritis associated with any systemic or neurologic disease in adults. We included instruments developed using classic test theory or Rasch analysis approaches. We used established quality criteria to assess content development, validity, reliability, and responsiveness, grading multiple domains from A (high quality) to C (low quality).
From 3142 screened abstracts we identified five PROM instruments potentially applicable to optic neuritis: three differing versions of the National Eye Institute (NEI)-Visual Function Questionnaire (VFQ): the 51-item VFQ; the 25-item VFQ and a 10-item neuro-ophthalmology supplement; and the Impact of Visual Impairment Scale (IVIS), a constituent of the Multiple Sclerosis Quality of Life Inventory (MSQLI) handbook, derived from the Functional Assessment of Multiple Sclerosis (FAMS). Psychometric appraisal revealed the NEI-VFQ-51 and 10-item neuro module had some relevant content development but weak psychometric development, and the FAMS had stronger psychometric development using Rasch Analysis, but was only somewhat relevant to optic neuritis. We identified no content or psychometric development for IVIS.
There is unmet need for a PROM with strong content and psychometric development applicable to optic neuritis for use in virtual care pathways and clinical trials to support drug marketing authorisation.

© 2023. The Author(s).

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ABOUT THE EXPERTS

Jesse Panthagani,Charles O'Donovan,Olalekan Lee Aiyegbusi,Xiaoxuan Liu,Susan Bayliss,Melanie Calvert,Konrad Pesudovs,Alastair K Denniston,David J Moore,Tasanee Braithwaite

Jesse Panthagani

University Hospitals Birmingham, Birmingham, UK.

Charles O’Donovan

School of Immunology and Microbiology, King’s College London, London, UK. charles.odonovan@kcl.ac.uk.

Olalekan Lee Aiyegbusi

Centre for Patient Reported Outcomes Research (CPROR), Institute of Applied Health Research, Birmingham Health Partners for Regulatory Science and Innovation, NIHR Birmingham Biomedical Research Centre, NIHR Applied Research Collaboration West Midlands, and NIHR Birmingham-Oxford Blood and Transplant Research Unit (BTRU) in Precision Transplant and Cellular Therapeutics, University of Birmingham, Birmingham, B15 2TT, UK.

Xiaoxuan Liu

Institute of Inflammation and Ageing, University of Birmingham, University Hospitals Birmingham, Health Data Research UK, London, UK.

Susan Bayliss

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Melanie Calvert

Centre for Patient Reported Outcomes Research (CPROR), Institute of Applied Health Research, Birmingham Health Partners for Regulatory Science and Innovation, NIHR, Birmingham Biomedical Research Centre, NIHR Surgical Reconstruction and Microbiology Centre, NIHR Applied Research Collaboration West Midlands, and NIHR Birmingham-Oxford Blood and Transplant Research Unit (BTRU) in Precision Transplant and Cellular Therapeutics, University of Birmingham, Birmingham, B15 2TT, UK.

Konrad Pesudovs

University of New South Wales, New South Wales, Australia.

Alastair K Denniston

Institute of Inflammation and Ageing, and Centre for Patient Reported Outcomes Research (CPROR), Institute of Applied Health Research, Birmingham Health Partners for Regulatory Science and Innovation, NIHR Birmingham-Oxford Blood and Transplant Research Unit (BTRU) in Precision Transplant and Cellular Therapeutics, University of Birmingham, University Hospitals Birmingham, Health Data Research UK, London, UK.

David J Moore

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Tasanee Braithwaite

School of Immunology and Microbiology, King’s College London, and The Medical Eye Unit, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, UK.