For a study, researchers sought to compare small, intermediate, and large-middle molecule clearance and the expression of inflammatory markers in long-hour hemodialysis patients using Solacea-190H (asymmetric cellulose triacetate [ATA]) and FX-80 dialyzers.
About 10 home hemodialysis patients were recruited for this pilot, randomized cross-over experiment. The trial lasted 8 weeks, with each dialyzer being used for 4 weeks. In serum and dialysate samples, the removal of small (urea, phosphate, creatinine, and indoxyl sulfate [IS]), middle and large-middle molecules (beta-2 microglobulin [β2M], albumin), and inflammation markers (interleukin-6 [IL-6], malondialdehyde-modified low-density lipoprotein [MDA-LDL], and alpha-1 microglobulin [α1M]
At the fourth week of each dialyzer series, reduction ratios [RR] were computed for variables, and the findings were reported as the difference in mean RR between dialyzers. There was no difference in clearance of small molecules, with differences in mean RR for urea -2.43 (95% CI -6.44, 1.57; P=.19), creatinine -1.82 (95% CI -5.50, 1.85; P=.28) and phosphate -2.61 (95% CI -12.45, 7.23; P=.55); clearance of middle and large-middle molecules, with differences in mean RR (range) for β2M 2.2 (95% CI −3.2, 7.7; P=.35), IS 1.8 (95% CI −9.5, 13; P=.72) and albumin −0.6 (95% CI −5.5, 4.2; P=.77). There was no induction of inflammatory markers such as IL-6 15.2 (95% CI -31.9, 62.2; P=.47), MDA-LDL -8.1 (95% CI -22.1, 5.8; P=.21), and α1M -3.50 (95% CI -29.2, 22.2; P=.76). The findings of dialysate removal were obtained concurrently.
There was no difference in clearance of small, intermediate, and large-middle molecules or expression of inflammatory markers between dialyzers in the investigation.
Reference: onlinelibrary.wiley.com/doi/10.1111/nep.14030
