The study was done with the purpose to evaluate the effects of 0.01% and 0.02% atropine eye drops on myopia progression, pupil diameter, and accommodative amplitude in myopic children.
It was a cohort study that assessed 400 myopic children divided into three groups. They wore SV spectacles, with one drop of atropine eye drop applied to both eyes once nightly. 120 control children only wore SV spectacles so that the results can be compared.
There were significant differences in the change in AL and SER between the three groups. Between baseline and the 12-month visit, the overall change in accommodative amplitude was 1.50±0.25D, 1.61±0.31D, and change in pupil diameter was 0.78±0.42 mm, 0.69±0.39 mm, with 0.02% and 0.01% atropine, respectively. There was no statistical difference that was observed in the change difference in accommodative amplitude and pupil diameter between the two atropine groups, whereas the accommodative amplitude and pupil diameter in the control group remained stable.
The study concluded through its findings 0.02% atropine eye drops had a better effect on myopia progression than 0.01% atropine, but 0.02% and 0.01% atropine showed similar effects on pupil diameter and accommodative amplitude after 12 months of treatment.
Reference: https://bjo.bmj.com/content/104/11/1535
