Eosinophilic esophagitis (EoE) is a chronic, relapsing oesophagal inflammatory condition. Researchers wanted to see if peripheral eosinophils may predict oesophagal eosinophilia and if they correlate with histological abnormalities such basilar hyperplasia, spongiosis, microabscesses, lymphocyte count, and neutrophil count. Following IRB permission, a retrospective chart review was performed on EoE patients aged 18 years. Biopsies from 57 EoE patients were examined. Patient demographics, symptoms, and complete blood counts with differentials collected during endoscopies or within a month following the operation were all reported. The association between peripheral absolute eosinophil count (AEC) and peak esophageal eosinophil count was shown to be substantial. Participants with biopsies indicating continuing disease activity or active status had a higher mean AEC of 577.41 202.60 compared to inactive subjects with a mean of 305.26 526.67. When the individuals were broadly split using 500 AEC as a cut-off, it was discovered that 24 of the 27 EoE inactive patients had AEC counts less than or equal to 500, whereas 32 of the 66 EoE active patients had AEC counts more than 500.
Active EoE state was associated with a greater mean AEC when compared to inactive status; nevertheless, AEC was not shown to be a sensitive technique for detecting active EoE.
Reference:https://journals.lww.com/jpgn/Fulltext/2020/05000/Do_Histological_Features_of_Eosinophilic.15.aspx
