The aim is To compare clinical characteristics and outcomes of children admitted to the PICU for severe acute respiratory syndrome coronavirus 2–a related illness with or without multisystem inflammatory syndrome in children. The secondary objective was to identify explanatory factors associated with the outcome of critical illness defined by a composite index of in-hospital mortality and organ system support requirement. Diagnosis of a multisystem inflammatory syndrome in children was associated with a longer duration of hospitalization as compared to a non-multisystem inflammatory syndrome in children (7.5 d[interquartile range, 5–11] vs 5.3 d [interquartile range, 3–11 d]; p < 0.01). Critical illness occurred in 164 patients (41.6%) and was more common in patients with the multisystem inflammatory syndrome in children compared with those without (55.6% vs 30.9%; p < 0.01). Multivariable analysis failed to show an association between critical illness and age, race, sex, greater than or equal to three signs and symptoms, or greater than or equal to two comorbidities among the multisystem inflammatory syndrome in children cohort. Among non-multisystem inflammatory syndrome in children patients, the presence of greater than or equal to two comorbidities was associated with greater odds of critical illness.
Reference link- https://journals.lww.com/pccmjournal/fulltext/2021/07000/coronavirus_disease_2019_associated_picu.3.aspx
