The coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients.
Post-hoc analysis of the international, multicentre, “real-world” HOPE COVID-19 registry. All patients aged ≥65 years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65-74 and ≥75 years, was performed. The primary endpoint was all cause in-hospital mortality.
1,520 patients aged ≥65 years (60.3% male, median age of 76 [IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P < 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age ≥75 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8,06), peripheral oxygen saturation at admission <92% (OR 5.85), severe lymphopenia (1 (OR 8.31) to be independent predictors of mortality.
Patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older. Age ≥75 years, dementia, peripheral oxygen saturation 1 were independent predictors of mortality in this population.
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.
About The Expert
Víctor Manuel Becerra-Muñoz
Iván J Núñez-Gil
Charbel Maroun Eid
Marcos García Aguado
Rodolfo Romero
Jia Huang
Alba Mulet
Fabrizio Ugo
Francesco Rametta
Christoph Liebetrau
Alvaro Aparisi
Inmaculada Fernández-Rozas
María C Viana-Llamas
Gisela Feltes
Martino Pepe
Luis A Moreno-Rondón
Enrico Cerrato
Sergio Raposeiras-Roubín
Emilio Alfonso
Ana Carrero-Fernández
Luis Buzón-Martín
Mohammad Abumayyaleh
Adelina Gonzalez
Antonio Fernández Ortiz
Carlos Macaya
Vicente Estrada
Cristina Fernández-Pérez
Juan José Gómez-Doblas
References
PubMed