Clinical characteristics and immunosuppressants management of coronavirus disease 2019 in solid organ transplant recipients.

Apr 14, 2020

Contributor: Zibiao Zhong,Qiuyan Zhang,Haoyang Xia,Aiping Wang,Wenjin Liang,Wei Zhou,Lihua Zhou,Xiao Liu,Lingzhang Rao,Zhifeng Li,Zhiyong Peng,Pingzheng Mo,Yong Xiong,Ye Shaojun,Yanfeng Wang,Qifa Ye

Clinical characteristics and immunosuppressants management of coronavirus disease 2019 in solid organ transplant recipients.

Over 1,000,000 cases of coronavirus disease 2019 (COVID-19) have been confirmed since the worldwide outbreak began. Not enough data on infected solid organ transplant (SOT) recipients are available, especially data about the management of immunosuppressants. We report two cases of COVID-19 in two transplant recipients, with different treatments and prognoses. The first patient received liver transplantation due to hepatitis B virus-related hepatocellular carcinoma and was confirmed to have COVID-19 nine days later. Following a treatment regimen consisting of discontinued immunosuppressant use and low-dose methylprednisolone-based therapy, the patient developed acute rejection but eventually recovered. The other patient had undergone a renal transplant from a living related donor 17 years ago, and was admitted to the hospital because of persistent fever. This patient was also diagnosed with COVID-19. His treatment regimen consisted of reduced immunosuppressant use. No signs of rejection were observed during the regimen. In the end, the patient successfully recovered from COVID-19. These effectively treated cases can provide a basis for immunosuppressant management of COVID-19-positive SOT recipients.
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About The Expert

Zibiao Zhong

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Qiuyan Zhang

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Haoyang Xia

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Aiping Wang

Department of Cardiovascular Medicine, Wuchang Hospital of Wuhan University of Technology, Wuhan, Hubei, China, 430063.

Wenjin Liang

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Wei Zhou

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Lihua Zhou

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Xiao Liu

Department of Cardiovascular Medicine, Wuchang Hospital of Wuhan University of Technology, Wuhan, Hubei, China, 430063.

Lingzhang Rao

Department of Cardiovascular Medicine, Wuchang Hospital of Wuhan University of Technology, Wuhan, Hubei, China, 430063.

Zhifeng Li

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, 430071.

Zhiyong Peng

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, 430071.

Pingzheng Mo

Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, 430071.

Yong Xiong

Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, 430071.

Ye Shaojun

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Yanfeng Wang

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

Qifa Ye

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China, 430071.

References

PubMed