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Surgery General

A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression.

Mar 10, 2020

The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exo...

New Onset Depression and Anxiety After Spinal Fusion Surgery: Incidence and Risk Factors.

Mar 10, 2020

Retrospective database study.We sought to investigate trends and risk factors for new onset anxiety and/or depression within six months after elective spine surgery.Surgery represents a stressful expe...

Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain.

Mar 10, 2020

To evaluate the SUMMIT-07 trial opioid withdrawal results of NKTR-181 (oxycodegol), a new molecular entity mu-opioid receptor agonist.Phase 3, enriched-enrollment, double-blind, randomized-withdrawal ...

Risk of New Fractures in Vertebroplasty for Multiple Myeloma. A Retrospective Study.

Mar 10, 2020

Vertebroplasty is a percutaneous minimally invasive procedure indicated for vertebral collapse pain treatment. Among the known complications of the procedure is the augmented risk of new vertebral fra...

Full agonist opioid prescribing by primary care clinicians after buprenorphine training.

Mar 10, 2020

While primary care clinicians are being trained to use buprenorphine for the treatment of Opioid Use Disorder (OUD) in order to increase access to addiction treatment, it is not known what impact suc...

A Phylogenetic Analysis of HCV Transmission, Relapse, and Reinfection Among People Who Inject Drugs Receiving Opioid Agonist Therapy.

Mar 10, 2020

Understanding hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is essential for HCV elimination. We aimed to differentiate reinfections from treatment failures and to identify...

Limited Surgical Coverage

Mar 10, 2020

Your health insurance has limited surgical coverage, but you'd be amazed at what I can do with nail clippers and duct tape. ...

Lumbar Puncture Guidance

Mar 09, 2020

Data indicate that nearly 400,000 lumbar punctures (LPs) are performed annually for either diagnostic workup or therapeutic relief in the United States. Regular referral to radiology for assistance ...

Red herrings in crossmatching kidneys for transplant.

Mar 05, 2020

Crossmatching of prospective renal transplant donors against recipients is a mandatory component of the transplant workup, being performed for over 40 years now. Allografting patients with human leuko...

HEPATITIS C TREATMENT OF RENAL TRANSPLANT AND CHRONIC KIDNEY DISEASE PATIENTS: EFFICACY AND SAFETY OF DIRECT-ACTING ANTIVIRAL REGIMENS CONTAINING SOFOSBUVIR.

Mar 05, 2020

Direct-acting antivirals have revolutionized hepatitis C treatment, also for patients with chronic kidney disease (CKD), but some controversy exists regarding the use of sofosbuvir (SOF) in patients w...

A Multimodal Computer-Aided Diagnostic System for Precise Identification of Renal Allograft Rejection: Preliminary Results.

Mar 05, 2020

Early assessment of renal allograft function post-transplantation is crucial to minimize and control allograft rejection. Biopsy-the gold standard-is used only as a last resort due to its invasiveness...

Simultaneous Endocardial and Epicardial Delineation of 3D Reentrant Ventricular Tachycardia.

Mar 05, 2020

Mechanisms of scar-related ventricular tachycardia (VT) are largely based on computational and animal models that portray a 2-dimensional view.The authors sought to delineate the human VT circuit with...

"Fossa navicularis" and "septum glandis": A "flow-control chamber" for the male urethra?

Mar 05, 2020

A clear understanding of the normal anatomy of the glanular urethra is essential for anatomical reconstruction of the male urethra. In hypospadias surgery, tubularization of the neourethra over a cath...

A Multidisciplinary Technique for Concurrent Panniculectomy-Living Donor Renal Transplantation.

Mar 05, 2020

Recently, it has been shown that panniculectomy concurrent to living donor renal transplantation is a safe option for management of renal transplant recipients with a large focal pannus. This combined...

Lymphatic Leaks of the Thigh and Inguinal Region: Combined Plastic Surgery Approaches for an Effective Treatment Algorithm.

Mar 05, 2020

Surgical procedures interfering with the draining nodes in the inguinal region carry the intrinsic risk of lymphatic complications. Lesions of the inguinal lymphatic network can lead to lymphocele or ...

[Plastic surgery in the German second medical licensing examination].

Mar 05, 2020

 There are 230 defined objectives in the national competency-based catalogue of learning goals in surgery (NKLC) for undergraduate surgical education in Germany. These teaching objectives should be ...

A method to prevent cerebrospinal fluid leakage: Reinforcing acellular dermal matrix.

Mar 05, 2020

In neurosurgical cases, problems related to wound healing can vary from simple wound dehiscence to multilayer defects. This study demonstrates an effective method to prevent persistent cerebrospinal f...

An Update on Level of Evidence Trends in Facial Plastic Surgery Research.

Mar 05, 2020

Knowledge of the quality of evidence in facial plastic surgery research is essential for the implementation of evidence-based practices. The purpose of this study is to provide an update over the pas...

Job satisfaction, engagement, and burnout in the population of orthopedic surgeon and neurosurgeon trainees in mainland China.

Mar 05, 2020

In China, orthopedics and neurosurgery are among the most desired majors for medical students. However, little is known about the working and living status of specialists in these two fields. This stu...

Review of Physician Referrals to Orthopedic Spine versus Neurosurgery.

Mar 05, 2020

Previous studies have reported what patients value while choosing their surgeon, but there are no studies exploring the patterns of referral to spine surgeons among primary care physicians (PCPs). Thi...

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