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Sleep Disorders

Effects of Lemborexant on the Pharmacokinetics of Oral Contraceptives: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Females.

Jun 10, 2021

Lemborexant is a dual orexin receptor antagonist approved in multiple countries including the United States, Canada, and Japan for the treatment of insomnia in adults. As women of childbearing potenti...

Association between perceived stress and depression among medical students during the outbreak of COVID-19: The mediating role of insomnia.

Jun 10, 2021

The purpose of this study was to explore the association between perceived stress and depression among medical students and the mediating role of insomnia in this relationship during the COVID-19 pand...

Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed.

Jun 03, 2021

To describe lemborexant for the treatment of insomnia () in adults using number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH). Lemborexant data were ...

Automatic segmentation of the pharyngeal airway space with convolutional neural network.

Jun 03, 2021

This study proposed and investigated the performance of a deep learning based three-dimensional (3D) convolutional neural network (CNN) model for automatic segmentation of the pharyngeal airway space ...

Sleep disorders in Wilson's disease.

Jun 03, 2021

Wilson's disease (WD) is a rare genetic disorder that leads to copper overload, mainly in the liver then, in the brain. Patients with WD often complain about sleep disorders. We aimed to explore them....

Relationships between insomnia and alcohol and cocaine use frequency with aggression among veterans engaged in substance use treatment.

May 24, 2021

Veterans with substance use problems have rates of partner and non-partner violence that typically exceed the general population. Sleep problems may exacerbate violence and maintain addictive behavior...

The impact of obstructive sleep apnea on bronchiolitis severity in children with Down syndrome.

May 24, 2021

Acute bronchiolitis commonly causes respiratory failure in children ≤2 years, and is particularly severe in those with Down syndrome (DS). Obstructive sleep apnea (OSA), common in DS, is also associ...

Obstructive Sleep Apnea Risk Treatment & Dementia Risk

May 21, 2021

“Although a growing body of research suggests that obstructive sleep apnea (OSA) is a common, yet undiagnosed, risk factor for cognition impairment in older adults, few studies have examined whether...

Sleep disturbance and memory dysfunction in early multiple sclerosis.

May 06, 2021

Sleep-dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but...

An efficient design for real-time obstructive sleep apnea OSA detection through esophageal pressure Pes signal.

May 06, 2021

Obstructive Sleep Apnea (OSA) is a potentially common sleep disorder in which the upper airways are collapsed either partially or completely. The golden standard method for treating OSA, is the full n...

A community study of the risk for obstructive sleep apnea and respiratory inflammation in an adult Chinese population.

Apr 15, 2021

ObjectivesWe aimed to investigate the relationship between obstructive sleep apnea (OSA) risk and respiratory inflammation evaluated by the exhaled breath condensate (EBC) interleukin-6 (IL-6) and pla...

New frontiers in pharmacologic obstructive sleep apnea treatment: A narrative review.

Apr 15, 2021

Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing characterized by intermittent partial or complete closure of the upper airway during sleep. If left untreated, OSA i...

The natural history of insomnia: Does sleep extension differentiate between those that do and do not develop chronic insomnia?

Apr 15, 2021

According to the "3P model" of insomnia, the variable that mediates the transition from acute insomnia (AI) to chronic insomnia is "sleep extension" (the behavioural tendency to expand sleep opportuni...

The impact of cannabis use on vasomotor symptoms, mood, insomnia and sexuality in perimenopausal and postmenopausal women: a systematic review.

Mar 25, 2021

This study aimed to evaluate the published data on the effect of cannabis use in perimenopausal and postmenopausal women to alleviate menopausal symptoms, insomnia and anxiety.Databases searched inclu...

Impact of COVID-19 pandemic on the sleep quality of medical professionals in Brazil.

Mar 25, 2021

Coronavirus pandemic began in China in 2019 (COVID-19), causing not only public health problems but also great psychological distress, especially for physicians involved in coping with the virus or th...

Feasibility of a video-based cognitive behavioral therapy for insomnia in French adult cancer outpatients: results from the Sleep-4-All-1 study.

Mar 25, 2021

Insomnia affects up to 63% of patients with cancer. Cognitive behavioral therapy for insomnia (CBT-I) is considered to be the non-pharmacological gold standard treatment, but it remains underutilized ...

Efficacy and adherence of noninvasive ventilation treatment in children with Down syndrome.

Mar 18, 2021

Children with Down syndrome (DS) have an increased prevalence of obstructive sleep apnea (OSA). Noninvasive ventilation (NIV) is a common modality of OSA treatment in this cohort. This study aimed to ...

Predictive clinical exam findings in post-tonsillectomy hemorrhage.

Mar 18, 2021

Post tonsillectomy hemorrhage (PTH) is a common complication of tonsillectomy. Our objectives were to: 1) Examine the postoperative course of patients presenting to St. Christopher's Hospital for Chil...

The Effect of Panax ginseng on Genitourinary Syndrome in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Mar 18, 2021

Menopause and estrogen deprivation cause a rise in the number of urogenital tract complaints.This study was conducted to assess the effectiveness of ginseng on genitourinary syndrome.This randomized t...

Impedance-pH monitoring Profile of Patients with Reflux and Obstructive Sleep Apnea Syndrome: A Controlled Study.

Feb 25, 2021

To study the profile of patients with obstructive sleep apnea syndrome (OSAS) and laryngopharyngeal reflux (LPR) at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring (HEM...

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