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Opioids

Low-dose ketamine for acute pain control in the emergency department: A systematic review and meta-analysis.

Oct 26, 2020

There has been increased interest in the use of low dose ketamine (LDK) as an alternative analgesic for the management of acute pain in the emergency department (ED). The objective of this systematic ...

Is alexithymia related to retention and relapses in patients with substance use disorders?: A one year follow-up study.

Oct 12, 2020

Alexithymia is related to a higher severity of substance use disorders (SUD); however, few longitudinal studies have been performed on how alexithymia impacts treatment outcomes. This study aims to ev...

Sexual addiction 25 years on: A systematic and methodological review of empirical literature and an agenda for future research.

Oct 12, 2020

In 1998, Gold and Heffner authored a landmark review in Clinical Psychology Review on the topic of sexual addiction that concluded that sexual addiction, though increasingly popular in mental health s...

Increased thalamic volume and decreased thalamo-precuneus functional connectivity are associated with smoking relapse.

Oct 08, 2020

The thalamus, with the highest density of nicotinic acetylcholine receptor (nAChR) in the brain, plays a central role in thalamo-cortical circuits that are implicated in nicotine addiction. However, l...

Psychiatric emergency care during Coronavirus 2019 (COVID 19) pandemic lockdown: results from a Department of Mental Health and Addiction of northern Italy.

Sep 28, 2020

The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population.We aimed to compare the number ...

Engagement under difficult conditions: Caring for patients with acute abdominal pain across the acute-care chain: A qualitative study.

Aug 24, 2020

Studies report that patients with acute abdominal pain do not always receive optimal care and can experience poor pain management, safety failures, and emotional harm. Deeper understanding of how heal...

Interprofessional Collaboration and Involvement of Parents in the Management of Painful Procedures in Newborns.

Aug 17, 2020

Newborns are subject to many painful procedures. Pharmacological and non-pharmacological approaches alone are not enough, and it is necessary to consider other contributing elements such as the envir...

High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats.

Aug 13, 2020

While cigarette smoking rates have been steadily decreasing over the past decade, there has been a dramatic increase in nicotine use via e-cigarettes, especially during adolescence. Adolescent e-cigar...

Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.

Aug 06, 2020

Brief interventions of environmental enrichment (EE) or the glycine transporter-1 inhibitor Org24598 administered with cocaine-cue extinction training were shown previously to inhibit reacquisition of...

Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates.

Aug 03, 2020

Preterm and full-term neonates undergo many painful procedures during their hospitalization in the neonatal intensive care unit. Unrelieved and repeated pain can have important repercussions on their ...

Do Meso-Limbic Gene Expression Findings from Mouse Models of Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder?

Jul 30, 2020

Animal models of drug use have been employed for over 100 years to facilitate the identification of mechanisms governing human substance use and addiction. Most cross-species research on drug use/ad...

Pandemic Presents New Hurdles, And Hope, For People Struggling With Addiction

Jun 04, 2020

Before Philadelphia shut down to slow the spread of the coronavirus, Ed had a routine: most mornings he would head to a nearby McDonald’s to brush his teeth, wash his face and — when he had th...

ASCO: Gastric Cancer Patients Respond to Trastuzumab Deruxtecan

Jun 02, 2020

Overall survival also extended with conjugate treatment In a small, phase II trial, patients with advanced gastric cancer were far more likely to respond to conjugate therapy with trastuzumab deruxte...

How COVID-19 Has Impacted the Opioid Crisis

May 07, 2020

When it comes to rates of infection and addiction, both the coronavirus pandemic and the opioid epidemic disproportionately impact the poorest and most vulnerable members of society. As physicians, it...

Individual differences in biological regulation: Predicting vulnerability to drug addiction, obesity, and other dysregulatory disorders.

Apr 28, 2020

Physiological regulation is so fundamental to survival that natural selection has greatly favored the evolution of robust regulatory systems that use both reactive and preemptive responses to mitigate...

Interventions to Support Family Caregivers in Pain Management: A Systematic Review.

Apr 28, 2020

Family caregivers encounter many challenges when managing pain for their loved ones. ​​There is a lack of clear recommendations on how to prepare caregivers in pain management.To evaluate existing...

Profile of cases discussed in innovative tele-ECHO mentoring program on addiction management.

Apr 28, 2020

NIMHANS ECHO (Extension for Community Healthcare Outcomes) model uses a video conferencing app to connect multiple community health care teams simultaneously with addiction treatment specialists and b...

Prevalence and predictors of hazardous alcohol use among tuberculosis patients: the need for a policy on joint tuberculosis-alcohol collaborative activities in India.

Apr 24, 2020

Collaborative activities to address tobacco addiction among tuberculosis (TB) patients are in place in India. The research was carried out to estimate the prevalence and to determine the predictors of...

Metasynthesis of Factors That Influence Parents' Participation in Pain Management for Their Infants in the NICU.

Apr 12, 2020

To metasynthesize the results of qualitative studies on the factors that affect parents' participation in pain management for their infants during procedures in the NICU.We conducted a literature sear...

GABAergic neurons in the insular cortex play an important role in cue-morphine reward memory reconsolidation.

Apr 12, 2020

There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-dru...