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Opioids

DEA Disconnect Leads to Buprenorphine Bottlenecks.

Nov 16, 2020

To describe a buprenorphine dispensing bottleneck resulting from a pharmacist-perceived Drug Enforcement Administration "cap" on the amount of buprenorphine that can be ordered or stocked.Expert revie...

Comparing an All-RN Unit to a Mixed-Skill Unit at a Hospital.

Nov 16, 2020

The aim of this study was to assess the differences in patient complications as well as patient and staff satisfaction between a mixed-skill unit and an all-registered nurse (RN) unit.It is recognized...

Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.

Nov 12, 2020

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pai...

The Relationship between Online Sexual Solicitation and Internet Addiction in Adolescents.

Nov 12, 2020

The purpose of this study is to investigate the association between online sexual solicitation (OSS) and internet accessibility, usage, and addiction in adolescents. The study was conducted with 48 ad...

Which is the best analgesia treatment for total knee arthroplasty: Adductor canal block, periarticular infiltration, or liposomal bupivacaine? A network meta-analysis.

Nov 02, 2020

To review all randomized controlled trials (RCTs) comparing the analgesic efficacy of adductor canal block (ACB), periarticular infiltration (PAI), and any other mode of these treatments in analgesia,...

Use of cryoanalgesia as a postoperative pain management for open pectus carinatum repair.

Oct 29, 2020

Cryoanalgesia has shown to have safety and efficacy as an adjunct post-operative pain management for Nuss procedure. One retrospective study reported its efficacy for analgesia with the Ravitch proce...

SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.

Oct 29, 2020

Specificity proteins (SPs) have pro-oncogenic functions in cancer cells, ranging from cancer cell proliferation, migration, invasion, and angiogenesis. There is strong evidence that several antineopla...

Immersive virtual reality vs. non-immersive distraction for pain management of children during bone pins and sutures removal: A randomized clinical trial protocol.

Oct 26, 2020

To examine the efficacy of an immersive virtual reality distraction compared with an active non-immersive distraction, such as video games on a tablet, for pain and anxiety management and memory of pa...

Low-dose ketamine for acute pain control in the emergency department: A systematic review and meta-analysis.

Oct 26, 2020

There has been increased interest in the use of low dose ketamine (LDK) as an alternative analgesic for the management of acute pain in the emergency department (ED). The objective of this systematic ...

Is alexithymia related to retention and relapses in patients with substance use disorders?: A one year follow-up study.

Oct 12, 2020

Alexithymia is related to a higher severity of substance use disorders (SUD); however, few longitudinal studies have been performed on how alexithymia impacts treatment outcomes. This study aims to ev...

Sexual addiction 25 years on: A systematic and methodological review of empirical literature and an agenda for future research.

Oct 12, 2020

In 1998, Gold and Heffner authored a landmark review in Clinical Psychology Review on the topic of sexual addiction that concluded that sexual addiction, though increasingly popular in mental health s...

Increased thalamic volume and decreased thalamo-precuneus functional connectivity are associated with smoking relapse.

Oct 08, 2020

The thalamus, with the highest density of nicotinic acetylcholine receptor (nAChR) in the brain, plays a central role in thalamo-cortical circuits that are implicated in nicotine addiction. However, l...

Psychiatric emergency care during Coronavirus 2019 (COVID 19) pandemic lockdown: results from a Department of Mental Health and Addiction of northern Italy.

Sep 28, 2020

The current COVID-19 pandemic and the consequent containment measures are leading to increasing mental health issues both in psychiatric patients and general population.We aimed to compare the number ...

Engagement under difficult conditions: Caring for patients with acute abdominal pain across the acute-care chain: A qualitative study.

Aug 24, 2020

Studies report that patients with acute abdominal pain do not always receive optimal care and can experience poor pain management, safety failures, and emotional harm. Deeper understanding of how heal...

Interprofessional Collaboration and Involvement of Parents in the Management of Painful Procedures in Newborns.

Aug 17, 2020

Newborns are subject to many painful procedures. Pharmacological and non-pharmacological approaches alone are not enough, and it is necessary to consider other contributing elements such as the envir...

High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats.

Aug 13, 2020

While cigarette smoking rates have been steadily decreasing over the past decade, there has been a dramatic increase in nicotine use via e-cigarettes, especially during adolescence. Adolescent e-cigar...

Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy.

Aug 06, 2020

Brief interventions of environmental enrichment (EE) or the glycine transporter-1 inhibitor Org24598 administered with cocaine-cue extinction training were shown previously to inhibit reacquisition of...

Systematic review and meta-analysis of olfactive stimulation interventions to manage procedural pain in preterm and full-term neonates.

Aug 03, 2020

Preterm and full-term neonates undergo many painful procedures during their hospitalization in the neonatal intensive care unit. Unrelieved and repeated pain can have important repercussions on their ...

Do Meso-Limbic Gene Expression Findings from Mouse Models of Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder?

Jul 30, 2020

Animal models of drug use have been employed for over 100 years to facilitate the identification of mechanisms governing human substance use and addiction. Most cross-species research on drug use/ad...

Pandemic Presents New Hurdles, And Hope, For People Struggling With Addiction

Jun 04, 2020

Before Philadelphia shut down to slow the spread of the coronavirus, Ed had a routine: most mornings he would head to a nearby McDonald’s to brush his teeth, wash his face and — when he had th...

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