Jan 18, 2021

Lumateperone is a mechanistically novel agent FDA-approved for the treatment of schizophrenia. Efficacy and favorable tolerability of lumateperone were demonstrated in 2 short-term placebo-controlled ...

Jan 18, 2021

Alzheimer's disease (AD) is characterized by accumulation of tau and amyloid-beta in the brain, and recent evidence suggests a correlation between associated protein aggregates and trace elements, suc...

Jan 18, 2021

To evaluate the performance of a Random Forest (RF) classifier on Transcranial Magnetic Stimulation (TMS) measures in patients with Mild Cognitive Impairment (MCI).We applied a RF classifier on TMS me...

Jan 18, 2021

The multi-target-directed ligands have been regarded as the promising multifunctional agents for the treatment of Alzheimer's disease (AD). Based on our previous work, a series of genistein-O-alkylami...

Jan 18, 2021

First, to investigate whether specific manic symptoms in preschool predict manic symptom severity in adolescence. Second, to investigate the interaction between family history (FH) of bipolar disorder...

Jan 18, 2021

Ketamine, a dissociative anaesthetic, has been used in the treatment of major depressive disorder (MDD) as a rapid acting antidepressant drug. Recent studies have shown that ketamine may increase the ...

Jan 18, 2021

The aim of this study is to explore mania as a network of its symptoms, inspired by the network approach to mental disorders.Network structures of both cross-sectional and temporal effects were measur...

Jan 18, 2021

Anhedonia is a core symptom of major depressive disorder (MDD). Two subtypes of anhedonia: anticipatory anhedonia and consummatory anhedonia has been recognized in MDD patients. However, our knowledge...

Jan 18, 2021

Patients with psychotic disorders report to apply more maladaptive and less adaptive emotion-regulation (ER) strategies compared to healthy controls. However, few studies have used experimental design...

Jan 18, 2021

Recent advances in mass spectrometry (MS)-based proteomics have vastly increased the quality and scope of biological information that can be derived from human samples. These advances have rendered cu...

Jan 18, 2021

COMT had been considered a promising candidate gene in pharmacogenetic studies in ADHD; yet the findings from these studies have been inconsistent. Part of these inconsistencies could be related to ep...

Jan 18, 2021

Mental health problems are common amongst adults with an Autism Spectrum Disorder (ASD). Stressful and traumatic life events can trigger or exacerbate symptoms of anxiety, depression and PTSD. In the ...

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...

Jan 18, 2021

Despite medicalization and legalization of marijuana use, factors influencing demand for marijuana among persons living with HIV (PLWH) are incompletely understood. This knowledge gap undermines effec...

Jan 18, 2021

Ankle fractures are a common orthopedic injury that frequently involves associated cartilage lesions, soft tissue damage, and a significant inflammatory burden. Despite studies revealing intra-articul...

Jan 18, 2021

Morphine has been long recognized as standard of care in the treatment of acute coronary syndrome (ACS) patients; however, its safety has recently been called into question due to a drug interaction w...

Jan 14, 2021

Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have tra...

Jan 14, 2021

Conventional treatment guidelines of schizophrenia do not necessarily provide solutions on clinically important issues.A total of 141 certified psychiatrists of the Japanese Society of Clinical Neurop...

Jan 14, 2021

To assess the efficacy and safety of citalopram in the acute and maintenance phases of bipolar depression in a randomized, double-blind, placebo-controlled trial.Between 2007 and 2014, 119 subjects wi...

Jan 14, 2021

Methylphenidate (MPH) is the most widely prescribed therapy for attention deficit hyperactivity disorder. Animal studies have shown a potential adverse effect of MPH exposure on male fertility. We exa...