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Psychiatry General

Nuclear localization of alpha-synuclein induces anxiety-like behavior in mice by decreasing hippocampal neurogenesis and pathologically affecting amygdala circuits.

Sep 25, 2023

Fear and anxiety are common in Parkinson's disease (PD) and may be caused by pathologies outside the dopaminergic system. Increasing evidence has shown that alpha-synuclein (α-syn) is involved in the...

From correlation to causation using directed topological overlap matrix: Applications in genomics.

Sep 25, 2023

Most causal discovery tools assume the local causal Markov condition. However, the theoretical assumptions that underlie the local causal Markov condition are often not met in practice. This is especi...

The relationship between subthreshold psychiatric symptoms and Internet Addiction in an Italian population.

Sep 25, 2023

Internet addiction (IA) is an emerging psychopathological entity, often comorbid with a variety of psychiatric disorders. Subthreshold psychopathology has recently emerged as a new field of research, ...

What's in the mind's eye of individuals with bipolar disorders: an exploration of the content and characteristics of mental images in different thymic phases.

Sep 25, 2023

Mental imagery, or 'seeing with the mind's eye' (Kosslyn . ), provokes strong emotional responses (Ji ., ). To date, there is a lack of data on the content and clinical characteristics (e.g. vividness...

Medical Misnomers are Murky: Time to Memorialize and Rename.

Sep 25, 2023

Misnomers have dogged medical practice seemingly since its inception. They may arise out of initial misunderstanding of the underlying disease process, a fanciful personification of the disease itself...

The Use of Dispensary-Obtained Tetrahydrocannabinol as a Treatment for Neuropsychiatric Symptoms of Dementia.

Sep 25, 2023

Neuropsychiatric symptoms (NPS) of dementia represent a large driver of health care costs, caregiver burden, and institutionalization of people with dementia. Management options are limited, and anti...

The role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: Evidence based on altered composition and function in a cross-sectional study.

Sep 18, 2023

We aimed to explore the interconnection between the weight-gain in schizophrenia patients with atypical antipsychotic treatment and gut microbiome.This study employed a cross-sectional design, encompa...

Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer's Disease - Evidence from an MRI-based Meta-Analysis.

Sep 18, 2023

Recent models of Alzheimer's Disease (AD) suggest that neuropathological changes of the medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the cholinergic Nucleus bas...

Low and very low lithium levels: Thyroid effects are small but still require monitoring.

Sep 18, 2023

Low doses of lithium, as might be used for mood or dementia prevention, do not carry the same renal, toxicity, and tolerability problems of doses used for prophylaxis or treatment of mania. However, t...

Bipolar At-Risk Criteria and Risk of Bipolar Disorder Over 10 or More Years.

Sep 18, 2023

Predicting the onset of bipolar disorder (BD) could facilitate preventive treatments. Among risk measures, bipolar at-risk (BAR) criteria have shown promise in predicting onset of bipolar disorder in ...

Forensic psychiatry patients, services, and legislation in Nunavut and Greenland.

Sep 11, 2023

Circumpolar regions face unique challenges in establishing and maintaining mental health care systems, including forensic psychiatry services. The scarcity of data and lack of evidence concerning the ...

Pretrauma risk factors and posttraumatic stress disorder symptoms following subsequent exposure: Multilevel and univariate meta-analytical approaches.

Sep 11, 2023

The endeavour to comprehend why certain individuals develop posttraumatic stress disorder (PTSD) symptoms subsequent to experiencing traumatic events, while others do not, underscores the paramount im...

Meta-analysis of the effects of adjuvant drugs in co-occurring bipolar and substance use disorder.

Sep 11, 2023

Individuals with bipolar disorder (BD) often have co-occurring substance use disorders (SUDs), which substantially impoverish the course of illness. Despite the importance of this dual diagnosis, the ...

Effect of ginger root powder on gastrointestinal bacteria composition, gastrointestinal symptoms, mental health, fatigue, and quality of life: A double-blind placebo-controlled trial.

Sep 11, 2023

Despite compositional alterations in gastrointestinal microbiota being purported to underpin some of the therapeutic effects of ginger, the effect of a standardized ginger supplement on gut microbiota...

The burden of major depressive disorder in the Middle East and North Africa region, 1990-2019.

Sep 11, 2023

Major depressive disorder (MDD) is one of the leading causes of disability. We aimed to report the MDD attributable prevalence, incidence and years lived with disability (YLDs) in the Middle East and ...

Effects of institutional rearing and foster care intervention on error monitoring and externalizing behaviors in adolescence.

Sep 11, 2023

Children raised in institutions display deficits in error monitoring and increased psychopathology. Deficits in error monitoring might be a pathway for the emergence of psychopathology in previously i...

Impact of a pre-test measurement of alcohol craving in cue-exposure studies: relationship with social desirability and demand effects.

Sep 04, 2023

Craving is one of the most studied concepts in the field of addiction. It is often investigated with repeated measure experimental designs using self-reported scales. However, the explicit nature of s...

Hydralazine inhibits neuroinflammation and oxidative stress in APP/PS1 mice via TLR4/NF-κB and Nrf2 pathways.

Sep 04, 2023

Alzheimer's disease (AD) is a common chronic progressive neurodegenerative disorder, and curative treatment has not been developed. The objective of this study was to investigate the potential effects...

[Features of the neurocognitive profile of patients with protracted and chronic endogenous manic and manic-delusional states].

Sep 04, 2023

To study the neurocognitive profile of patients with protracted and chronic endogenous manic and manic-delusional states (EMDS).Thirty-two female patients, aged 18 to 55 years (mean age 36.2±10.2 yea...

Cardiovascular variations in patients with major depressive disorder versus bipolar disorder.

Sep 04, 2023

Differentiating depression in major depressive disorder and bipolar disorder is challenging in clinical practice. Therefore, reliable biomarkers are urgently needed to differentiate between these dise...

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