Mar 15, 2021

Bipolar disorder (BD) with psychotic symptoms is a specific phenotype that presents greater risk of relapse and worse outcomes than nonpsychotic BD, however, the underlying mechanisms remain unknown a...

Mar 15, 2021

Bipolar (BP) disorder, especially BP depression is common and yet remains enigmatic until the emergence of mania. The rates and risk factors of conversion from unipolar (UP) depression to BP disorder ...

Mar 15, 2021

Anxiety and stress are adaptive responses to threat that promote harm avoidance. In particular, prior work has shown that anxiety induced in humans using threat of unpredictable shock promotes behavio...

Mar 15, 2021

The COVID-19 pandemic has and will continue to result in negative mental health outcomes such as depression, anxiety and traumatic stress in people and populations throughout the world. A population m...

Mar 11, 2021

This study aimed to determine if sleep disturbances may mediate the relationship between panic symptoms and depression in patients with panic disorder (PD).Electronic medical records were retrospectiv...

Mar 11, 2021

Individuals with a schizophrenia-spectrum disorder (SSD) and those at familial high-risk (FHR) for SSDs experience social difficulties that are related to neural abnormalities in the network of brain ...

Mar 11, 2021

Second-generation antipsychotics (SGAs) for schizophrenia show different risk profiles, whose evidence has been evaluated through comparative reviews on randomized controlled trials (RCTs) and observa...

Mar 11, 2021

This paper demonstrates the utility of latent classes in evaluating the effect of an intervention on an outcome through multiple indicators of mediation. These indicators are observed intermediate var...

Mar 11, 2021

Problematic internet use (PIU) has become public health concern, particularly among adolescents and emerging adults. There is growing interest concerning the potential impacts of early maladaptive sch...

Mar 11, 2021

To identify overload and associated factors among caregivers of adult patients receiving palliative care.Descriptive, quantitative, and cross-sectional study addressing 40 adults under palliative care...

Mar 11, 2021

Interferon-γ (IFN-γ) is a proinflammatory cytokine that activates glial cells. IFN-γ is increased in the plasma and brain of Parkinson's disease patients, suggesting its potential role in the disea...

Mar 11, 2021

Drug discovery and development for Alzheimer's disease (AD) are complex and challenging due to the higher failure rate in the drug development process. The overproduction and deposition of Aβ senile ...

Mar 11, 2021

An emotional intelligence (EI) deficit has been noticed in euthymic bipolar spectrum disorder (BD) patients. However, whether this deficit is affected by mood or subtype is unclear. The aim of this s...

Mar 11, 2021

Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. Interleukin-6 (...

Mar 11, 2021

Bipolar disorder is an affective disorder characterized by rapid fluctuations in mood ranging from episodes of depression to mania, as well as by increased impulsivity. Previous studies investigated t...

Mar 11, 2021

Chronic stress during early life, such as exposure to social conflict or deficits in parental care, can have persistent adverse behavioural effects. Offspring in a rodent model of maternal depression ...

Mar 08, 2021

To evaluate the impact of a psychoeducational, mobile health intervention based on cognitive behavioural therapy and mindfulness-based approaches on the mental health of healthcare workers at the fron...

Mar 08, 2021

A recent report from the European Sleep Research Society's task force "Beyond AHI" discussed an issue that has been a long-term subject of debate - what are the best metrics for obstructive sleep apno...

Mar 08, 2021

Breakdown of paracellular and vascular pathways and activated neuroimmune and oxidative pathways was established in (deficit) schizophrenia. The aim of this study was to delineate (a) the differences ...

Mar 08, 2021

There is increasing knowledge regarding the role of the microbiome in modulating brain and behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain communication in hu...