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Psychiatry General

Psychometric properties of Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV).

Mar 18, 2021

The purpose of this study was to evaluate the psychometric properties of Structured Clinical Interview Version for DSM-5 (R) Clinical Version (SCID-5-CV) in a population of patients with psychiatric d...

Transcriptome-wide association study reveals two genes that influence mismatch negativity.

Mar 18, 2021

Mismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, ...

The impact of ovariectomy and chronic estrogen treatment on gene expression in the rat cortex: Implications for psychiatric disorders.

Mar 18, 2021

Estrogens, via estrogen-mediated changes in CNS function, have been suggested to be beneficial in the treatment of several psychiatric disorders. Few studies have used transcriptomic technologies to d...

A thematic analysis of the perceptions of a community-based exercise program on the health and well-being of ageing adults.

Mar 18, 2021

This study explores a weekly community-based exercise program (CBEP) for ageing adults in Gippsland, Victoria, Australia. This program aims to improve the health and well-being of ageing adults and wa...

The AD tau core spontaneously self-assembles and recruits full-length tau to filaments.

Mar 18, 2021

Tau accumulation is a major pathological hallmark of Alzheimer's disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear. Taking advantage of the identification of ...

Predicting Parkinson's disease trajectory using clinical and neuroimaging baseline measures.

Mar 18, 2021

Predictive biomarkers of Parkinson's Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work uses measures derived from restin...

Relation of medication adherence to cognitive functions in egyptian patients with bipolar I disorder.

Mar 18, 2021

Nonadherence to medication regimens is frequently reported in bipolar I disorder (BDI) patients. However, little is known about the relationship between cognitive functions and adherence in BDI. To es...

Odour identification impairment is a trait but not a disease-specific marker for bipolar disorders: Comparisons of bipolar disorder with different episodes, major depressive disorder and schizophrenia.

Mar 18, 2021

Olfactory deficits have been reported in bipolar disorder, but this finding is controversial. This study investigated whether olfactory deficit can serve as a specific marker for bipolar disorder by c...

The Neurostimulation of the Brain in Depression Trial: Protocol for a Randomized Controlled Trial of Transcranial Direct Current Stimulation in Treatment-Resistant Depression.

Mar 18, 2021

Major depressive disorder (MDD) is the second highest cause of disability worldwide. Standard treatments for MDD include medicine and talk therapy; however, approximately 1 in 5 Canadians fail to resp...

An altered global DNA methylation status in women with depression.

Mar 18, 2021

Sparse studies have shown that specific biomarkers of a global DNA methylation status may be related to various mental diseases and states, including: bipolar disorder (BD), anxiety and major depressi...

Trajectories of depression and anxiety in Chinese high school freshmen: Associations with Internet addiction.

Mar 18, 2021

Most previous studies focused on the associations of depression and anxiety with Internet addiction (IA) have used variable-centered approaches. This study aims to explore the distinct developmental t...

"Doc McStuffins: Doctor for a Day" Virtual Reality (DocVR) for Pediatric Preoperative Anxiety and Satisfaction - A Feasibility Study.

Mar 18, 2021

Preoperative anxiety is a common occurrence among children and is associated with a host of maladaptive post-operative behaviors. Consequently, increased attention has been placed on interventions to ...

A Pilot Economic Evaluation of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorder as an Addition and Alternative to Traditional Therapy.

Mar 18, 2021

Computer-based delivery of cognitive behavioral therapy (CBT) may be a less costly approach to increase dissemination and implementation of evidence-based treatments for alcohol use disorder (AUD). Ho...

Toward a Point-of-Need Bioluminescence-Based Immunoassay Utilizing a Complete Shelf-Stable Reagent.

Mar 18, 2021

Enzyme-linked immunosorbent assays (ELISAs) are used extensively for the detection and quantification of biomolecules in clinical diagnostics as well as in basic research. Although broadly used, the i...

Continuation rate for asenapine and brexpiprazole treatment in patients with schizophrenia.

Mar 15, 2021

The current study sought to compare the treatment continuation rates of asenapine and brexpiprazole while specifically investigating the factors influencing this index and the clinical efficacy of bre...

Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia.

Mar 15, 2021

It is widely held that schizophrenia involves an active process of peripheral inflammation that induces or reflects brain inflammation with activation of microglia, the brain's resident immune cells. ...

Brain age prediction in schizophrenia: Does the choice of machine learning algorithm matter?

Mar 15, 2021

Brain-predicted age difference (brainPAD) has been used in schizophrenia to assess individual-level deviation in the biological age of the patients' brain (i.e., brain-age) from normative reference br...

Problematic usage of the internet and eating disorder and related psychopathology: a multifaceted, systematic review and meta-analysis.

Mar 15, 2021

Eating disorders are widespread illnesses with significant impact. There is growing concern about how those at risk of eating disorders overuse online resources to their detriment. We conducted a pre-...

Weight gain as a risk factor for progressive neurochemical abnormalities in first episode mania patients: a longitudinal magnetic resonance spectroscopy study.

Mar 15, 2021

We previously reported that bipolar disorder (BD) patients with clinically significant weight gain (CSWG; ⩾7% of baseline weight) in the 12 months after their first manic episode experienced greater...

Efficacy of Active vs Sham Intermittent Theta Burst Transcranial Magnetic Stimulation for Patients With Bipolar Depression: A Randomized Clinical Trial.

Mar 15, 2021

Major depressive episodes in bipolar disorder are common and debilitating. Repetitive transcranial magnetic stimulation is well established in the treatment of major depressive disorder, and the inter...

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