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Psychiatry General

C9orf72 Repeat Expansion Initially Presenting as Late-onset Bipolar Disorder With Psychosis.

Oct 16, 2023

C9orf72 expansion is the most common genetic abnormality in behavioral variant frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis. Although psychiatric prodromes are common in C9orf72 e...

Lifestyle in bipolar disorder: A cross-sectional study.

Oct 16, 2023

Modifiable lifestyle behaviors are important factors for improving mental health, yet there has been a lack of research studying lifestyle as a multidimensional construct in bipolar disorder (BD). The...

Reinforcement learning and working memory in mood disorders: A computational analysis in a developmental transdiagnostic sample.

Oct 16, 2023

Mood disorders commonly onset during adolescence and young adulthood and are conceptually and empirically related to reinforcement learning abnormalities. However, the nature of abnormalities associat...

Anxiety in Parkinson's Patients: What's Timing Got to Do with It?

Oct 16, 2023

Parkinson's Disease (PD) affects over 10 million people worldwide. Many PD patients experience comorbid anxiety disorders, which have been correlated with reduced quality of life and can manifest at ...

Tobacco smoking related to childhood trauma mediated by cognitive control and impulsiveness in severe mental disorders.

Oct 09, 2023

People with severe mental disorders (SMDs) show an increased prevalence of tobacco smoking compared to the general population. Tobacco smoking and other adult adverse health behaviors have been associ...

G.T. MSRS On-Line Calculator Targeting the Early Diagnosis of Mixed Affective States: the Multicenter Study Project Design on the Approbation and Validity of the Three Language Versions of the Rating Scale.

Oct 09, 2023

Mixed affective states (MS) are often misdiagnosed by the clinicians and lead to the inappropriate treatment strategies contributing to the severe forms, poor outcome with higher rates of comorbid con...

Psychiatric rehabilitation and cognitive deficit for treatment-resistant depression.

Oct 09, 2023

Patients with TRD often experience persistent impairment of affective, psychosocial, and cognitive function, which impedes their recovery. The continuation of pharmacotherapy for patients with TRD rem...

Bidirectional relations between problematic smartphone use and bedtime procrastination among Chinese university students: Self-control as a mediator.

Oct 09, 2023

Based on theoretical and empirical evidence, this study examined the longitudinal relationship between problematic smartphone use and bedtime procrastination and the potential mediating role of self-c...

A randomized controlled trial comparing the efficacy of nifedipine and enalapril in the postpartum period.

Oct 09, 2023

Postpartum hypertension is a common medical complication of pregnancy and is associated with increased healthcare utilization, including unplanned interactions with the medical system and readmission,...

Antipsychotic dose reduction and discontinuation versus maintenance treatment in people with schizophrenia and other recurrent psychotic disorders in England (the RADAR trial): an open, parallel-group, randomised controlled trial.

Oct 02, 2023

Maintenance antipsychotic medication is recommended for people with schizophrenia or recurrent psychosis, but the adverse effects are burdensome, and evidence on long-term outcomes is sparse. We aimed...

Cocaine use disorder effects on blood oxytocin levels and OXTR DNA methylation.

Oct 02, 2023

Substance use disorders have been associated with alterations in the oxytocinergic system, but few studies have investigated both the peptide and epigenetic mechanisms potentially implicated in the re...

Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data.

Oct 02, 2023

To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits pred...

Understanding people's experiences of the formal health and social care system for co-occurring heavy alcohol use and depression through the lens of relational autonomy: A qualitative study.

Oct 02, 2023

Heavy alcohol use and depression commonly co-occur. However, health and social care services rarely provide coordinated support for these conditions. Using relational autonomy, which recognizes how so...

Are There Any Differences in Clinical and Biochemical Variables between Bipolar Patients with or without Lifetime Psychotic Symptoms?

Oct 02, 2023

Psychotic symptoms occur in more than half of patients affected by Bipolar Disorder (BD) and are associated with an unfavorable course of the disorder. The objective of this study is to identify the d...

An observer-rated strategy for differentiating schizophrenic and manic states in inpatient settings.

Oct 02, 2023

Differentiating schizophrenia from mania in acutely psychotic patients can be difficult, but is important in determining immediate and subsequent management. Such differentiation is generally addresse...

The binding of a c-MYC promoter G-quadruplex to neurotransmitters: An analysis of G-quadruplex stabilization using DNA melting, fluorescence spectroscopy, surface-enhanced Raman scattering and molecular docking.

Oct 02, 2023

The interactions of several neurotransmitter and neural hormone molecules with the c-MYC G-quadruplex DNA sequence were analyzed using a combination of spectroscopic and computational techniques. The ...

Excessive Sedentary Time Is Associated with Cognitive Decline in Older Patients with Minor Ischemic Stroke.

Sep 25, 2023

Cognitive impairment is commonly seen after acute ischemic stroke (AIS). Sedentary behaviors increase the risk of dementia among community dwelling population.This study aims to investigate the associ...

Enhanced methamphetamine sensitisation in a rat model of the brain-derived neurotrophic factor Val66Met variant: Sex differences and dopamine receptor gene expression.

Sep 25, 2023

Brain-derived neurotrophic factor (BDNF) and the Val66Met polymorphism may play a role in the development of psychosis and schizophrenia. The aim of this study was to investigate long-term effects of ...

Executive functioning trajectories and their prospective association with inflammatory biomarkers in schizophrenia and non-psychiatric comparison participants.

Sep 25, 2023

Cognitive change in people with schizophrenia (PwS) is challenging to assess, but important to understand. Previous studies with limited age ranges and follow-up were subject to practice effects. Cont...

Relevance of early management by proton-pump inhibitor in acute upper gastro-intestinal tract disorder: A scoping review.

Sep 25, 2023

Proton-pump inhibitors (PPI) are frequently used in the emergency and general practice settings in several clinical presentations linked to acute upper gastro-intestinal tract disorders as abdominal o...

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