Mar 28, 2022

Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring ...

Mar 28, 2022

Stress is a major risk factor for the development of both schizophrenia and depression, and comorbidity between the two is common in schizoaffective disorders. However, the effects of stress exposure ...

Mar 28, 2022

This article provides an overview and retrospective on metacognitive training for psychosis (MCT), which first appeared approximately 2 decades ago. We recount how our empirical understanding of psych...

Mar 28, 2022

Gut microbiota has emerged as a crucial target of gut-brain axis to influence depression. Zhi-Zi-Chi decoctions (ZZCD), as a classic oral formula in clinic, is widely applied in depression treatment n...

Mar 28, 2022

Western psychiatry emerged as a medical specialty caring for the mentally ill over the course of the late 18th and early 19th centuries. This emergence was a contingent process, dependent on the co-oc...

Mar 28, 2022

Cariprazine is a piperazine derivative approved by the USFDA in 2015 as a novel atypical antipsychotic drug (APD) to treat adults with schizophrenia and bipolar manic or mixed episodes in adults. Howe...

Mar 28, 2022

Children who are exposed to parental substance use disorder (SUD) have a higher risk of SUD themselves. This study examines the extent to which the association between parental and own SUD is conditio...

Mar 28, 2022

The purpose of this study was to determine the test-retest reliability and construct validity of tools to assess how balance confidence (BC) and state anxiety (SA) change with progressively increasing...

Mar 24, 2022

TP0473292 (the active component in TS-161) is a prodrug of new metabotropic glutamate (mGlu) 2/3 receptor antagonist that was being investigated for the treatment of depression patients. The safety, t...

Mar 23, 2022

Cognitive improvement following antipsychotic drugs appears to require redox modulation via neurotrophins such as a brain-derived neurotrophic factor in people with schizophrenia (SCZ) (BDNF). For a s...

Mar 23, 2022

The mechanisms through which kappa opioid receptor (KOR) agonists generate psychotomimetic effects are largely unclear, despite the fact that manipulation of this receptor has sparked interest for the...

Mar 23, 2022

Depression and suicidal conduct have both been linked to the serotonin 1A (5-HT1A) receptor. Lower resting cortisol levels are connected with increased 5-HT1A receptor binding, and both distinguish su...

Mar 23, 2022

Inattention deficit hyperactivity disorder (ADHD), a high placebo response can minimize medication–placebo differences, compromising the development of novel medications. For a study, researchers so...

Mar 23, 2022

Energy drinks (EDs) increase driving performance while decreasing drowsiness and exhaustion, but alcohol has the reverse effect. Although it is a popular combination among young people, the consequenc...

Mar 23, 2022

As senior people's life expectancy has increased, so has the prevalence of cardiovascular and cerebrovascular disorders in this demographic. All kinds of cognitive problems related to cerebrovascular ...

Mar 23, 2022

For a study, it was determined that the neuropathology of bipolar disease (BD) was linked to oxidative stress. Single-nucleotide polymorphisms (SNPs) in the antioxidative genes superoxide dismutase 2 ...

Mar 22, 2022

Evidence showed that neuroaxonal damage was linked to a major depressive illness and that neurofilament light chain (NFL) is a biomarker of neuroaxonal injury. Furthermore, proinflammatory cytokines w...

Mar 22, 2022

The extended-release pill ansofaxine (LY03005) is a possible triple reuptake inhibitor of serotonin, norepinephrine, and dopamine. For a study, researchers examined the effectiveness, safety, and dose...

Mar 22, 2022

For a randomized, double-blind (DB), parallel-group research, investigators sought to compare the effectiveness and safety of paliperidone palmitate 6-month (PP6M) formulation to paliperidone palmitat...

Mar 22, 2022

Previous animal and human research suggested that stress regulating systems such as the hypothalamic-pituitary-adrenal (HPA) axis and the endocannabinoid (ECB) system might play a role in the developm...