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Psychiatry General

Depressive symptom trajectories and polygenic risk scores in individuals with an immune-mediated inflammatory disease.

Apr 25, 2022

To develop group-based trajectories of depressive symptoms in immune-mediated inflammatory disease (IMID) to understand their evolution and identify any associated factors, with the overall goal of id...

Community-Based Social Interventions For People With Severe Mental illness (SMI)

Apr 20, 2022

People who suffer from severe mental illness (SMI) are one of society's most stigmatized groups. Clinicians, policymakers, and persons with SMI themselves all value interventions that attempt to promo...

Cross-disorder and disorder-specific deficits in social functioning among schizophrenia and alzheimer's disease patients.

Apr 18, 2022

Social functioning is often impaired in schizophrenia (SZ) and Alzheimer's disease (AD). However, commonalities and differences in social dysfunction among these patient groups remain elusive.Using da...

Phase 3b Multicenter, Prospective, Open-label Trial to Evaluate the Effects of a Digital Medicine System on Inpatient Psychiatric Hospitalization Rates for Adults With Schizophrenia.

Apr 18, 2022

Inpatient psychiatric admissions drive the financial burden of schizophrenia, and medication adherence remains challenging. We assessed whether aripiprazole tablets with sensor (AS; system includes i...

Speech Understanding in Manic and Depressive Episodes of Mood Disorders.

Apr 18, 2022

The aim of this study was to assess the perception of speech in adverse acoustic conditions during manic and depressive episodes of mood disorders.Forty-three patients with bipolar disorder (mania, N=...

Metabolic effects of adding Topiramate on Aripiprazole in bipolar patients aged between 6-18 years, a randomized, double-blind, placebo-controlled trial.

Apr 18, 2022

second-generation antipsychotics (SGAs) are associated with metabolic side effects in child and adolescents. The aim of this study is to evaluate the metabolic effects of adding topiramate on aripipra...

Comparing retinal changes measured by optical coherence tomography in patients with schizophrenia and their siblings with healthy controls: Are retinal findings potential endophenotype candidates?

Apr 11, 2022

The aim of our study is to examine whether differences in retinal structure may reflect endophenotypes for schizophrenia by comparing thicknesses of retinal layers between patients with schizophrenia,...

SSPNet: An interpretable 3D-CNN for classification of schizophrenia using phase maps of resting-state complex-valued fMRI data.

Apr 11, 2022

Convolutional neural networks (CNNs) have shown promising results in classifying individuals with mental disorders such as schizophrenia using resting-state fMRI data. However, complex-valued fMRI dat...

Efficacy, Safety, and Tolerability of Flexibly Dosed Ziprasidone in Children and Adolescents with Mania in Bipolar I Disorder: A Randomized Placebo-Controlled Replication Study.

Apr 11, 2022

To evaluate the acute efficacy, safety, and tolerability of flexibly dosed ziprasidone in children and adolescents with Bipolar I Disorder (BD-I). Participants, 10-17 years of age, meeting The crit...

Anticipating manic and depressive transitions in patients with bipolar disorder using early warning signals.

Apr 11, 2022

In bipolar disorder treatment, accurate episode prediction is paramount but remains difficult. A novel idiographic approach to prediction is to monitor generic early warning signals (EWS), which may m...

Recovery of trivalent and hexavalent chromium from chromium slag using a bipolar membrane system combined with oxidation.

Apr 11, 2022

Chromium slag (CS) with large quantities of multivalent Cr species (III and VI) generated during chromium salt production is hazardous to nature and living organisms. Furthermore, CS discharge leads t...

Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for MDD

Apr 08, 2022

The extended-release pill ansofaxine (LY03005) is a possible triple reuptake inhibitor of serotonin, norepinephrine, and dopamine. For a study, researchers sought to examine the effectiveness, safety,...

Paliperidone Palmitate 6-Month vs. 3-Month Injectable in Schizophrenia Patients

Apr 08, 2022

For a randomized, double-blind (DB), parallel-group research, researchers sought to compare the effectiveness and safety of paliperidone palmitate 6-month (PP6M) formulation to paliperidone palmitate ...

A Systematic Review of Childhood Adversity and Executive Functions Outcomes among Adults.

Apr 04, 2022

Exposure to adverse childhood experiences (ACEs) is linked to disruptions in typical neurodevelopment of brain structures and functioning, including changes in executive functions. Although the relati...

How do social factors relate to blunted facial affect in schizophrenia? A digital phenotyping study using ambulatory video recordings.

Apr 04, 2022

Clinical interviews and laboratory-based emotional induction paradigms provide consistent evidence that facial affect is blunted in many individuals with schizophrenia. Although it is clear that blunt...

A DSM-5-based tool to monitor concurrent mood and premenstrual symptoms: the McMaster Premenstrual and Mood Symptom Scale (MAC-PMSS).

Apr 04, 2022

Despite high co-morbidity between premenstrual dysphoric disorder and mood disorders, there is a gap of research-based tools to monitor concurrent premenstrual and mood symptoms. In this study, we dev...

The use of modern dopamine partial agonists in bipolar depression: is the evidence sound?

Apr 04, 2022

Bipolar depression is a leading cause of morbidity in patients with bipolar disorder (BD) with at least half of bipolar patients who initially present with a depressive episode. While several pharmaco...

The anticholinergic burden is not associated with cognitive impairments in patients treated by electroconvulsive therapy for treatment-resistant depression.

Apr 04, 2022

Electroconvulsive therapy (ECT) is the most effective non-pharmacological treatment for treatment-resistant depression (TRD) but can expose to transient cognitive impairments. Understanding factors un...

Childhood adversity and adulthood major depressive disorder.

Apr 04, 2022

Examine how specific types of childhood adversity are associated with clinical features and treatment in adults with Major Depressive Disorder (MDD).This is a secondary analysis of the 35-site VA Augm...

Self-Harm Among Adult Outpatients: Dialectical Behavior Therapy vs Usual Care

Mar 29, 2022

For a study, researchers sought to compare two low-intensity outreach programs with standard treatment to prevent suicidal conduct in outpatients who have recently had frequent suicidal thoughts. Outp...

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