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Psychiatry General

Theoretical procedures of the cross-cultural adaptation process of the Child Mania Rating Scale - Parent Version (CMRS-P) for the Brazilian context.

May 16, 2022

To describe the theoretical procedures of the cross-cultural adaptation process of the Child Mania Rating Scale - Parent Version (CMRS-P) for Brazil. METHOD: Seven steps were carried out: (1) translat...

Effectiveness of remote home monitoring for patients with Chronic Obstructive Pulmonary Disease (COPD): systematic review.

May 16, 2022

Although remote home monitoring (RHM) has the capacity to prevent exacerbations in patients with chronic obstructive pulmonary disease (COPD), evidence regarding its effectiveness remains unclear. The...

Correlation between FDG-PET brain hypometabolism and PTSD symptoms in temporal lobe epilepsy.

May 16, 2022

The relationship between post-traumatic stress disorder (PTSD) and focal epilepsy is poorly understood. It has been hypothesized that there is a complex and reciprocal potential reinforcement of the s...

Allostatic load index in patients with multiple sclerosis: A case-control study.

May 09, 2022

Elevated allostatic load (AL) index is a cumulative measure of biological dysregulations associated with stress exposure. It has been reported that stress plays an important role in the pathophysiolog...

A Local Genetic Correlation Analysis Provides Biological Insights Into the Shared Genetic Architecture of Psychiatric and Substance Use Phenotypes.

May 09, 2022

Global genetic correlation analysis has provided valuable insight into the shared genetic basis between psychiatric and substance use disorders. However, little is known about which regions disproport...

A qualitative exploration of daily path and daily routine among people in Ukraine who inject drugs to understand associated harms.

May 09, 2022

Patterns of movement, heterogeneity of context, and individual space-time patterns affect health, and individuals' movement throughout the landscape is shaped by addiction, meeting basic needs, and ma...

Can pediatric bipolar disorder be successfully treated when comorbid with conduct disorder? A secondary analysis of clinical trials of risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole.

May 09, 2022

Pediatric bipolar disorder (BP) is frequently comorbid with conduct disorder (CD) and its presence adds to the morbidity of BP. While there are no known pharmacological treatments for CD, pediatric BP...

Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype.

May 09, 2022

Bipolar disorders are defined by recurrences of depressive and manic episodes. The pathophysiology is still unknown, and translating clinical symptoms into behaviors explorable in animal models is cha...

Continuum beliefs and the perception of similarities and differences to a person with depression.

May 02, 2022

Both continuum beliefs (i.e., that mental disorder exists on a spectrum of normative behavior patterns) and the perception of similarities to a person with schizophrenia have shown mixed effects on re...

A Systematic Review of the Effectiveness and Safety of Droperidol for Pediatric Agitation in Acute Care Settings.

May 02, 2022

Agitation in children in acute care settings poses significant patient and staff safety concerns. While behavioral approaches are central to reducing agitation and oral medications are preferred, pare...

Associations of presenting symptoms and subsequent adverse clinical outcomes in people with unipolar depression: a prospective natural language processing (NLP), transdiagnostic, network analysis of electronic health record (EHR) data.

May 02, 2022

To investigate the associations of symptoms of mania and depression with clinical outcomes in people with unipolar depression.A natural language processing electronic health record study. We used netw...

Exploring reasons for MD-PhD trainees' experiences of impostor phenomenon.

May 02, 2022

Acceptance into U.S. MD-PhD dual-degree programs is highly competitive, and the lengthy training program requires transitioning between multiple phases (pre-clinical-, PhD-research-, and clinical-trai...

Factors that influence the emotional impact of memory problems in older adults: A qualitative descriptive study.

May 02, 2022

Associations among psychological health and memory concerns in older adults are well-established, but much of this research is quantitative.This study examined how memory problems influence emotional ...

Deep Learning Identifies Robust Gender Differences in Functional Brain Organisation & Their Dissociable Links to Clinical Symptoms in Autism

Apr 29, 2022

Autism spectrum disorder (ASD) is a disorder with a wide range of symptoms that affects almost one in every 189 girls and one in every 42 boys. For a study, the researchers sought to find reliable fun...

Differential Potency of Antidepressants to Inhibit Serotonin & Norepinephrine Reuptake

Apr 25, 2022

Venlafaxine is a dual inhibitor of serotonin (5-HT) and norepinephrine reuptake. The precise dosage at which it begins to efficiently activate the norepinephrine transporter (NET) was unknown. Paroxet...

Relationship Between Dissociation & Antidepressant Effects of Esketamine Nasal Spray in TRD Patients

Apr 25, 2022

Data from two positive, pivotal, phase 3 trials of esketamine nasal spray (ESK) in treatment-resistant depression (TRD)—a short-term study (TRANSFORM-2) and a maintenance study (SUSTAIN-1)—were an...

Benzodiazepine & Z-Drug Use & the Risk of Developing Dementia

Apr 25, 2022

Benzodiazepine (BZDs) and Z-drugs (BZDRs) are among the most commonly given pharmaceuticals for anxiety and sleeplessness, particularly among the elderly. For a study, researchers sought to determine ...

Cognitive insight in individuals at ultra-high risk for psychosis compared to patients with first-episode psychosis and non-psychotic help-seeking youths.

Apr 25, 2022

Defective insight is a hallmark of schizophrenia. Less is known about insight in emerging psychosis. In this study a widely used measure of cognitive insight, the Beck Cognitive Insight Scale (BCIS), ...

Visual Event-Related Potentials under External Emotional Stimuli in Bipolar I Disorder with and without Hypersexuality.

Apr 25, 2022

Hypersexuality is related to functions of personality and emotion and is a salient symptom of bipolar I disorder especially during manic episode. However, it is uncertain whether bipolar I disorder wi...

Antidepressant Treatment and Manic Switch in Bipolar I Disorder: A Clinical and Molecular Genetic Study.

Apr 25, 2022

Affective switch is an important clinical issue when treating bipolar disorder. Though commonly seen in clinical practice, the benefits of prescribing antidepressants for bipolar depression are still ...

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