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Psychiatry General

Comprehensive Analysis of the Effects of Ketorolac Administration After Pancreaticoduodenectomy.

Mar 02, 2020

Outcome improvement is a major goal of pancreatic surgery. Such efforts include decreasing perioperative narcotic use to optimize care and reduce potential contributions to the opioid crisis. Ketorola...

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy.

Mar 02, 2020

Fibrils of alpha-synuclein are significant components of cellular inclusions associated with several neuropathological disorders including Parkinson's disease, multiple system atrophy and dementia wit...

Priming older adults and people with mild to moderate Alzheimer's disease problem-solving with false memories.

Mar 02, 2020

In two experiments we investigated whether older adult controls (OACs) and people with mild and moderate Alzheimer's disease (AD) benefit from false memory priming effects in subsequent problem-solvin...

Diagnostic potential of automated tractography in progressive supranuclear palsy variants.

Mar 02, 2020

Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkin...

Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.

Mar 02, 2020

Huntington's disease (HD) is an inherited, autosomal dominant disorder that is characteristically thought of as a degenerative disorder. Despite cellular and molecular grounds suggesting HD could also...

The Heart Failure with Preserved Ejection Fraction Conundrum-Redefining the Problem and Finding Common Ground?

Mar 02, 2020

Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (DHF) makes up more than half of all congestive heart failure presentations (CHF). With an ageing population, the case...

Broader phenotypic traits and widespread brain hypometabolism in spinocerebellar ataxia 27.

Mar 02, 2020

The goal of this study was to characterize a Swedish family with members affected by spinocerebellar ataxia 27 (SCA27), a rare autosomal dominant disease caused by mutations in fibroblast growth facto...

Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study.

Mar 02, 2020

Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co-occurrence often leads to worse outcomes. We investigated the developmental associations between ADH...

Long-lasting behavioral and neuroanatomical effects of postnatal valproic acid treatment.

Mar 02, 2020

Valproic acid (VPA) administered to mice during the early postnatal period causes social, cognitive, and motor deficits similar to those observed in humans with autism spectrum disorder (ASD). However...

Pericallosal artery aneurysm - Case report, literature review and management outcome.

Mar 02, 2020

Pericallosal artery aneurysms are rare. Very few cases of this vascular anomaly have been published from West Africa. We report the first case of a ruptured pericallosal artery (PCA) aneurysm managed ...

Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats.

Mar 02, 2020

This study is to explore the neuroprotective effects and involved glial scar of saffron (Crocus sativus L.) on the late cerebral ischemia in rats. Focal cerebral ischemia was induced by middle cerebra...

Risk factors for social isolation in post-hospitalized older adults.

Mar 02, 2020

Social isolation in older adults is associated with high rates of adverse health outcomes. Older adults who have had a recent significant health event are likely to be at risk of social isolation foll...

Advances in the In vitro and In vivo pharmacology of Alpha4beta2 nicotinic receptor positive allosteric modulators.

Mar 02, 2020

Receptors containing α4 and β2 subunits are a major neuronal nicotinic acetylcholine receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine addiction, with potential ...

Depressive Symptoms, Sleep Profiles and Serum Melatonin Levels in a Sample of Breast Cancer Patients.

Feb 28, 2020

Chronobiological changes have been detected in various physiological functions of patients with breast cancer, suggesting dysregulation in the pineal gland and melatonin secretion. This study aimed to...

Health-related quality of life before and during chemotherapy in patients with early-stage breast cancer.

Feb 28, 2020

Identify the main changes in the health-related quality of life (HRQoL) of women diagnosed with breast cancer (BC) undergoing chemotherapy.Prospective cohort study that included 33 women diagnosed wit...

Effects of tenuifolin on rest/wake behaviour in zebrafish.

Feb 28, 2020

Insomnia is a common sleep disorder with a high prevalence and substantial adverse consequences. There is growing interest in identifying novel therapeutics from herbal medicine. Tenuifolin is a major...

The long-term but not short-term use of benzodiazepine impairs motoric function and upregulates amyloid β in part through the suppression of translocator protein.

Feb 28, 2020

Many elderly American women use CNS depressant benzodiazepine (BZD) to ameliorate anxiety or insomnia. However, the chronic use of BZD (cBZD) is prevalent, causing adverse effects of BZD that include ...

Prevalence and associated risk factors of insomnia among pregnant women in China.

Feb 28, 2020

Insomnia is common during pregnancy but the prevalence and risk factors of insomnia in Chinese women during pregnancy is not well studied. This study aimed to examine the prevalence of insomnia and it...

[Age identity disorders (infantilism/ puerilism) in the psychopathological space of endogenous diseases].

Feb 28, 2020

A comparative psychopathological and psychometric analysis of age identity disorders (AID) - infantilism and puerilism - on the model of schizophrenia proceeding with hysterical symptoms.Results of th...

Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.

Feb 28, 2020

Phosphodiesterase 10 (PDE10) inhibitors have received much attention as promising therapeutic agents for central nervous system (CNS) disorders such as schizophrenia and Huntington's disease. Recently...

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