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Psychiatry General

TV 3326 for Alzheimer's dementia: a novel multimodal ChE and MAO inhibitors to mitigate Alzheimer's-like neuropathology.

Mar 10, 2020

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders and a well-recognized cause of dementia with ageing. In this review, we have represented the ChE and MAO inhibitory po...

Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.

Mar 10, 2020

As Parkinson's disease progresses, levodopa treatment loses efficacy, partly through the loss of the endogenous dopamine-synthesizing enzyme L-amino acid decarboxylase (AADC). In the phase I PD-1101 s...

Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease.

Mar 10, 2020

Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer's disease-related pathophysiology. This study hypothesized that exposing neuronal progenito...

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies.

Mar 10, 2020

Human cell-based neural organoids are increasingly being used for investigations of neurotoxicity, and to study the pathophysiology of neurodegenerative diseases. Here, we present a fast and robust me...

A longitudinal study on α-synuclein in plasma neuronal exosomes as a biomarker for Parkinson's disease development and progression.

Mar 10, 2020

The identification of reliable diagnostic and prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use of α-synuclein (α-syn) in plasma neuronal exo...

Antidepressant-Associated Mania in Bipolar Disorder: A Review and Meta-analysis of Potential Clinical and Genetic Risk Factors.

Mar 10, 2020

Antidepressants (ADs) play a valuable role in treating the depressive episodes of bipolar disorder. However, 14% of these individuals taking ADs experience AD-associated mania (AAM) within a few weeks...

Electroconvulsive therapy in a 91-year old Asian lady with late onset bipolar mania.

Mar 10, 2020

Electroconvulsive therapy (ECT) is safe and efficacious in the elderly population. However, clinicians are still weary to use it among the old-old population, citing safety concerns. Our case report h...

Examining the Neuropsychiatric Sequelae Postsurgical Resection of Adult Brain Tumors Through a Scoping Review.

Mar 10, 2020

Improving brain tumor survival rates have drawn increasing focus on neuropsychiatric and psychological outcomes.This review characterizes the literature on neuropsychiatric sequelae after neurosurgica...

Enhancing adherence to antipsychotic treatment for bipolar disorders. Comparison of mobile app-based psychoeducation, group psychoeducation, and the combination of both: protocol of a three-arm single-blinded parallel-group multi-centre randomised trial.

Mar 10, 2020

Group Psychoeducation (PE) is an effective strategy to enhance adherence to antipsychotic treatment in Bipolar Disorders (BD). However, it requires attendance to weekly sessions during a period of abo...

Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.

Mar 10, 2020

Studies utilizing optical coherence tomography (OCT) in psychosis have identified abnormalities in retinal cytoarchitecture. We aim to analyze retinal layer topography in psychosis and its correlation...

Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat.

Mar 10, 2020

Cerebral ischemia/reperfusion (I/R) injury causes cognitive deficits, excitotoxicity, neuroinflammation, oxidative stress and brain edema. Vitamin K2 (Menaquinone 4, MK-4) as a potent antioxidant can ...

From 'neurotic' to 'managing' mother: The 'medical career' experienced by mothers of a child diagnosed with Juvenile Idiopathic Arthritis.

Mar 10, 2020

Objective Despite increased research into how caring for a child diagnosed with juvenile idiopathic arthritis (JIA) affects mothers, more needs to be known about ways in which such experiences transfo...

[Benefits of mindfulness in pregnant women].

Mar 10, 2020

This article is intended to review the effect of mindfulness-based interventions on perinatal mental health. A search of the literature published until September 2019 in the Web of Science (WOS) datab...

The Effects of a Mindfulness-Based Program on the Incidence of Injuries in Young Male Soccer Players.

Mar 10, 2020

The authors tested the effectiveness of a mindfulness-based program in reducing sport-injury incidence. A total of 168 young male elite soccer players were randomly assigned to mindfulness and control...

[Clinical features of the attentional deficit and hyperactivity disorder in epilepsy].

Mar 10, 2020

Epilepsy and attention deficit and hyperactivity disorder (ADHD) are frequent conditions in pediatrics. Their association is frequent and complex, often sharing psychiatric comorbidity. Patients who p...

[Measurement of the theta / beta ratio with the quantified electroencephalogram in attention-deficit hyperactivity disorders].

Mar 10, 2020

Theta-Beta (T / B) ratio of the quantified electroencephalogram (EEGQ) in patients with attention deficit hyperactivity disorder (ADHD) constitutes a characteristic EEG variable of the primary disorde...

[Progression of symptoms in children with attention deficit and hyperactivity disorder in treatment with methylphenidate].

Mar 10, 2020

Attention deficit and hyperactivity disorder (ADHD) is a neurobiological disorder frequent in childhood. The main symptoms are attention disorder and/or impulsivity and/or hyperactivity. There are dif...

[Attention-deficit/hyperactivity disorder and substance abuse. Scientific evidence].

Mar 10, 2020

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental alteration of biological basis that started in childhood may persist during adolescence-youth and, despite what was believed unt...

An Examination of the Relationship Between Motivation, Physical Activity, and Wearable Activity Monitor Use.

Mar 10, 2020

Wearable physical activity (PA) monitors are widely promoted as a means to motivate people to be more active, but the motivational profile of users has never been assessed. This study's purpose was to...

New Onset Depression and Anxiety After Spinal Fusion Surgery: Incidence and Risk Factors.

Mar 10, 2020

Retrospective database study.We sought to investigate trends and risk factors for new onset anxiety and/or depression within six months after elective spine surgery.Surgery represents a stressful expe...

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