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Psychiatry General

Cognitive functioning, sleep quality, and work performance in non-clinical burnout: The role of working memory.

Apr 24, 2020

We investigated the relationship between cognitive functioning, work performance, and sleep in non-clinical burnout. In a working population, an online survey was conducted with additional online neur...

Predictors of criminal offending in a clinical sample of patients diagnosed with schizophrenia: A 6-year follow-up study.

Apr 24, 2020

Criminal behavior in schizophrenia has been associated with a number of risk factors including symptoms of schizophrenia, co-occurring personality disorders (PDs), substance abuse, intellectual and co...

Using Complexity Assessment to Inform the Development and Deployment of a Digital Dashboard for Schizophrenia Care: Case Study.

Apr 24, 2020

Health care is becoming more complex. For an increasing number of individuals, interacting with health care means addressing more than just one illness or disorder, engaging in more than one treatment...

The role of pituitary adenylyl cyclase-activating polypeptide in the motivational effects of addictive drugs.

Apr 24, 2020

Pituitary adenylyl cyclase activating polypeptide (PACAP) was originally isolated from the hypothalamus and found to stimulate adenylyl cyclase in the pituitary. Later studies showed that this peptide...

The Effect of Auditory Verbal Hallucinations on the Relationship between Spontaneous Brain Activity and intraventricular Brain Temperature in Patients with Drug-Naïve Schizophrenia.

Apr 24, 2020

Our recent study reported that adolescent-onset schizophrenia showed an uncoupling between intraventricular brain temperature (iBT) and local spontaneous brain activity (SBA). While auditory verbal ha...

Prevalence and predictors of hazardous alcohol use among tuberculosis patients: the need for a policy on joint tuberculosis-alcohol collaborative activities in India.

Apr 24, 2020

Collaborative activities to address tobacco addiction among tuberculosis (TB) patients are in place in India. The research was carried out to estimate the prevalence and to determine the predictors of...

Approach bias for erotic stimuli among heterosexual female college students who use pornography.

Apr 24, 2020

Repeated engagement in addictive behaviors may lead to relatively automatic action tendencies whereby individuals approach rather than avoid addictive stimuli. This study assessed whether an approach ...

First radiolabeling of a ganglioside with a positron emitting radionuclide - in vivo PET demonstrates low exposure of radiofluorinated GM1 in non-human primate brain.

Apr 24, 2020

Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as ...

Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein.

Apr 24, 2020

The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer's disease (AD). In this study, we found that ...

Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease.

Apr 24, 2020

Alzheimer's disease (AD) is a complex neurodegenerative disease with multiple pathological features. Multifunctional compounds able to simultaneously interact with several pathological components have...

GJ-4 alleviates Aβ-induced memory dysfunction in mice through protecting the neurovascular unit.

Apr 24, 2020

Alzheimer's disease (AD) is the most common neurodegenerative disease. AD has become an important social health problem but there are few therapeutic drugs. Many researchers devote to the development ...

Altered clearance of beta-amyloid from the cerebrospinal fluid following subchronic lead exposure in rats: Roles of RAGE and LRP1 in the choroid plexus.

Apr 24, 2020

Formation of amyloid plaques is the hallmark of Alzheimer's disease. Our early studies show that lead (Pb) exposure in PDAPP transgenic mice increases β-amyloid (Aβ) levels in the cerebrospinal flui...

The Clinical Effect of Electroconvulsive Therapy and Its Relationship with Serum Levels of MMP-9 and CXCL12 in Patients with Mania.

Apr 24, 2020

Electroconvulsive therapy (ECT) is a non-pharmacological method for the treatment of psychiatric disorders. The precise biochemical mechanism of the effects of ECT is not clear, and since the two fact...

20-Year Trends in the Pharmacologic Treatment of Bipolar Disorder by Psychiatrists in Outpatient Care Settings.

Apr 24, 2020

Pharmacological options for treating bipolar disorder have increased over the past 20 years, with several second-generation antipsychotics receiving regulatory approval in the 1990s. The authors descr...

Pseudobulbar Affect Presenting as Hypomania.

Apr 24, 2020

Pseudobulbar affect (PBA) is a behavioral syndrome associated with various neurological conditions that typically manifests as uncontrollable laughing or crying. PBA can significantly impact the quali...

More Purpose in Life and Less Novelty Seeking Predict Improvements in Self-Compassion During a Mindfulness-Based Intervention: The EXMIND Study.

Apr 24, 2020

Recently, a 4-week mindfulness-based intervention followed by a 4-week existential approach was found to be as effective for increasing self-compassion as an 8-week mindfulness-based intervention. The...

Cerebral Impaludation - An Ignoble Procedure between Two Nobel Prizes: Frontal Lobe Lesions before the Introduction of Leucotomy.

Apr 24, 2020

During the 20th century, only two persons have been awarded the Nobel Prize for psychiatric discoveries, Julius Wagner-Jauregg in 1927 for the introduction of malaria inoculation in dementia paralytic...

Effects of an Individualized Comprehensive Rehabilitation Program on impaired postural control in women with chronic pelvic pain: a randomized controlled trial.

Apr 24, 2020

To assess the effectiveness of an Individualized Comprehensive Rehabilitation Program (ICPR) on impaired postural control, pain, self-perceived health status and functionality in women with CPP.A rand...

Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants.

Apr 24, 2020

Deficient learning and memory are well-established pathophysiologic features of depression, however, mechanisms of the enhanced learning of aversive experiences associated with this disorder are poorl...

Neurobehavioral Changes Arising from Early Life Dopamine Signaling Perturbations.

Apr 24, 2020

Dopamine (DA) signaling is critical to the modulation of multiple brain functions including locomotion, reinforcement, attention and cognition. The literature provides strong evidence that altered DA ...

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