Apr 28, 2020

It is being increasingly recognized that human mucosal surfaces are not sterile but are colonized with microorganisms collectively known as the microbiome. The microbiome can alter brain functioning i...

Apr 28, 2020

To date, to our knowledge there are no studies regarding attitudes and experiences of outpatient medical personnel during a pandemic. This study's aim was to evaluate the impact of the COVID-19 pandem...

Apr 28, 2020

Lithium is the gold standard in treating bipolar affective disorders. As patients become increasingly older, drug-drug interactions leading to decreased excretion of lithium represent a key issue in l...

Apr 28, 2020

Phenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABA receptor and the α-δ subunit of voltage-dependent calcium channels. An increased number of repor...

Apr 28, 2020

The FiCTION trial compared co-primary outcomes (dental pain and/or infection) and secondary outcomes (child oral health-related quality of life [COHRQOL], child dental anxiety, cost-effectiveness, car...

Apr 28, 2020

Microbial association networks are frequently used for understanding and comparing community dynamics from microbiome datasets. Inferring microbial correlations for such networks and obtaining meaning...

Apr 28, 2020

The SBML standard is used in a number of online repositories for storing systems biology models, yet there is currently no Web-capable JavaScript library that can read and write the SBML format. This ...

Apr 28, 2020

Effects of drug treatment of clinical Alzheimer-type dementia (CATD) are uncertain.To summarize evidence on the effects of prescription drugs and supplements for CATD treatment.Electronic bibliographi...

Apr 28, 2020

Biomarker accuracy for Alzheimer disease (AD) is uncertain.To summarize evidence on biomarker accuracy for classifying AD in older adults with dementia.Electronic bibliographic databases (searched fro...

Apr 28, 2020

Receptor-operated activation of TRPC4 cation channels requires G proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca Concurrent stimulation of G pathway accelerates G activation of...

Apr 28, 2020

Background and aims Patients usually receive a prescription for morphine or another opioid at discharge after surgery. Several studies have shown that many patients do not step down but develop persis...

Apr 28, 2020

Background and aims There is very little published evaluation of the treatment of military veterans with chronic pain, with or without post-traumatic stress disorder. Few clinical services offer integ...

Apr 28, 2020

To address the opioid crisis, much work has focused on minimizing opioid supply to surgical patients upon hospital discharge. Research is limited regarding handover to primary care providers. The aim ...

Apr 28, 2020

Hypoxia induces reversible κ-opioid receptor (KOR) internalization similar to the internalization that is induced by KOR agonists. In the current study, we demonstrate that this KOR internalization i...

Apr 28, 2020

Is a maternal history of spontaneous abortion (SA) associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring?Our results suggest an association between maternal...

Apr 28, 2020

In this article, we present 3 studies examining patients with current or previous severe physical illness and their partners with respect to dyadic concordance, gender and role differences in mental d...

Apr 24, 2020

Sleep disturbance has been consistently identified as an independent contributor to suicide risk. Inflammation has emerged as a potential mechanism linked to both sleep disturbance and suicide risk. T...

Apr 24, 2020

The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the re...

Apr 24, 2020

Narcolepsy in childhood-adolescence is characterized by a high occurrence of psychiatric comorbidities. The most frequent psychiatric disorders reported in these patients are attention deficit/hyperac...

Apr 24, 2020

Opioids have, at most, small benefits for non-cancer pain in the medium and long-term but there is good evidence that they cause harm. The current study describes the characteristics and clinical stat...