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Psychiatry General

Do Meso-Limbic Gene Expression Findings from Mouse Models of Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder?

Jul 30, 2020

Animal models of drug use have been employed for over 100 years to facilitate the identification of mechanisms governing human substance use and addiction. Most cross-species research on drug use/ad...

Mother-to-Infant Bonding in Women with Postpartum Psychosis and Severe Postpartum Depression: A Clinical Cohort Study.

Jul 30, 2020

Mother-to-infant bonding is important for long-term child development. The aim of this study was to investigate bonding in women admitted to a Mother and Baby Unit with postpartum depression (PD, = 6...

Revision of the fear of cancer recurrence cognitive and emotional model by Lee-Jones et al with women with breast cancer.

Jul 30, 2020

Fear of cancer recurrence (FCR) is among the top unmet concerns reported by breast cancer survivors. Despite the sizable literature on FCR, few theoretical models have been empirically tested. One of ...

Convergent and divergent functional connectivityalterations of hippocampal subregions between short-term and chronic insomnia disorder.

Jul 30, 2020

Insomnia disorder (ID) is reclassified into short-term and chronic subtypes based on recent etiological advances, however, neural mechanisms underlying the subtypes are rarely examined. In this study,...

Development and initial psychometric evaluation of a radiotherapy-related symptom assessment tool, based on data from patients with brain tumours undergoing proton beam therapy.

Jul 30, 2020

Currently, no available tool easily and effectively measures both the frequency, intensity and distress of symptoms among patients receiving radiotherapy. A core symptom set (fatigue, insomnia, pain, ...

Lung cancer stigma: A concept with consequences for patients.

Jul 30, 2020

Patients with lung cancer (LC) report lower quality of life (QoL) and higher levels of psychological distress compared with other cancer populations. Lung cancer stigma (LCS) may in part explain these...

Variability in opioid prescribing practices among cardiac surgeons and trainees.

Jul 30, 2020

The opioid epidemic has become a major public health crisis in recent years. Discharge opioid prescription following cardiac surgery has been associated with opioid use disorder; however, ideal practi...

Effect of Intravenous Acetaminophen on Postoperative Hypoxemia After Abdominal Surgery: The FACTOR Randomized Clinical Trial.

Jul 30, 2020

Opioid-induced ventilatory depression and hypoxemia is common, severe, and often unrecognized in postoperative patients. To the extent that nonopioid analgesics reduce opioid consumption, they may dec...

A dose titration study of fentanyl buccal soluble film for breakthrough cancer pain in Taiwan.

Jul 30, 2020

Fentanyl buccal soluble film (FBSF), a new formulation of fentanyl, is developed for the treatment of breakthrough pain (BTP) in opioid-tolerant patients with cancer.This study aimed to assess the fea...

Screening and identification of secondary metabolites in the bark of to treat Alzheimer's disease by using molecular docking and molecular dynamics simulations.

Jul 30, 2020

Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) acts as a promising protein targets for which drug as an inhibitor can be designed to treat Alzheimer's Disease. Different flavonoids and a...

Diagnostic Value of the Early Heart-to-Mediastinum Count Ratio in Cardiac 123I-mIBG imaging for Parkinson's Disease.

Jul 30, 2020

Early diagnosis of Parkinson's disease (PD) is of primary importance. The delayed (3-4 h after injection) Iodine-123-Metaiodobenzylguanidine (123I-mIBG) scintigraphy has been proven to be effective in...

Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline.

Jul 30, 2020

The neuropathological confirmation of amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFT) remains the gold standard for a definitive diagnosis of Alzheimer's disease (AD). Nowadays, the in ...

Discussion on Relevance and Studies of Prescription Compatibility in Chinese Medicine.

Jul 30, 2020

With Chinese medicine (CM) gaining popularity in recent years, researchers and clinicians have put in much interest and effort into the makings and effects of it, especially after the recent announcem...

Restrictive eating disorders in children and adolescents: a comparison between clinical and psychopathological profiles.

Jul 30, 2020

DSM-5 describe three forms of restrictive and selective eating: Anorexia Nervosa-Restrictive (AN-R), Anorexia Nervosa-Atypical (AN-A), and Avoidant/Restrictive Food Intake Disorder (ARFID). While AN i...

Cardiovascular effects of repeated subanaesthetic ketamine infusion in depression.

Jul 30, 2020

Ketamine produces significant rapid-onset and robust antidepressant effects in patients with major depressive disorder. However, this drug also has transient cardiovascular stimulatory effects, and th...

Person-specific contributions of brain pathologies to progressive parkinsonism in older adults.

Jul 30, 2020

Mixed-brain pathologies are the most common cause of progressive parkinsonism in older adults. We tested the hypothesis that the impact of individual pathologies associated with progressive parkinsoni...

Evidence for the Confluence of Cigarette Smoking, Other Substance Use, and Psychosocial and Mental Health in a Sample of Urban Sexual Minority Young Adults: The P18 Cohort Study.

Jul 30, 2020

Sexual minority men (SMM) and transgender women (TW) are more likely to smoke cigarettes than heterosexual and cisgender peers, which may exacerbate existing disparities in mental and psychosocial hea...

Comparison of modafinil and pitolisant in narcolepsy: a non-inferiority meta-analytical approach.

Jul 27, 2020

To assess the non-inferiority of pitolisant, a new compound for the relief of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy, compared with modafinil.Randomized controlled trials (RCTs...

Sleep and circadian rhythm in response to the COVID-19 pandemic.

Jul 27, 2020

This commentary highlights the critical role of sleep as a public health issue, particularly during a stressful life period such as the COVID-19 pandemic, and provides evidence-based practical guideli...

Clozapine in the Time of COVID-19.

Jul 27, 2020

Clozapine is the most effective antipsychotic for treatment resistant schizophrenia but adverse reactions to clozapine include neutropenia. The current COVID-19 pandemic may raise specific concerns fo...

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