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Psychiatry General

Differential medication overuse risk of novel anti-migraine therapeutics.

Aug 20, 2020

Medication overuse headache is estimated to affect 2% of the population, and is ranked in the top 20 most disabling disorders due to its high level of disability. Several therapies used in the treatme...

Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer's disease.

Aug 20, 2020

Cerebrospinal fluid (CSF) neurofilament light (NfL) concentration has reproducibly been shown to reflect neurodegeneration in brain disorders, including Alzheimer's disease (AD). NfL concentration in ...

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.

Aug 20, 2020

Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early medi...

Structural Brain Network Correlated with Reading Impairment in Alzheimer's Disease.

Aug 20, 2020

Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and leads to dementia. AD is characterized by progressive declines in memory and, as the disease progresses, language ...

Associations of the Behavioral Assessment and Research System (BARS) neurobehavioral outcomes with attention problems in children living near coal ash storage sites.

Aug 20, 2020

Environmental exposures have been linked to childhood problems with overactivity, attention, and impulse control, and an increased risk of attention deficit hyperactivity disorder (ADHD) diagnosis. Tw...

The juxta-oral organ of Chievitz (organum yuxtaorale) updated: embryology, anatomy, function and pathology.

Aug 20, 2020

The Chievitz's organ or juxta-oral organ is a mysterious bilateral structure, phylogenetically preserved, which develops from the mouth epithelium as an invagination that loses connection to it in the...

Association between short-term air pollution exposure and attention-deficit/hyperactivity disorder-related hospital admissions among adolescents: A nationwide time-series study.

Aug 20, 2020

Long-term air pollution exposure has been suggested to increase the risk of attention-deficit/hyperactivity disorder (ADHD). However, the association between short-term air pollution exposure and ADHD...

Sleep medications and sleep disturbances across middle aged pre- or peri-menopausal women of different race and ethnicities: A SWAN pharmacoepidemiology cohort study.

Aug 20, 2020

Sleep disturbances are common, particularly in middle aged women. Prescription medications for this indication are increasingly used, despite uncertain safety. This study assessed prescription medicat...

Health-related quality of life 90 days after stroke assessed by the International Consortium for Health Outcome Measurement (ICHOM) standard set.

Aug 20, 2020

Stroke has detrimental effects in multiple health domains not captured by routine scales. The International Consortium for Health Outcome Measurement has developed a standardized set for self-reported...

Cortical Proteins and Cognitive Resilience in Community-Dwelling Older Persons

Aug 18, 2020

Identifying the right cortical proteins for cognitive resilience can offer a sustainable approach to developing effective treatments and prevention of Alzheimer's disease and other dementias. The obje...

Long-Term Outcomes of Childhood Sexual Abuse

Aug 18, 2020

One in 9 girls and 53 boys under the age of 18 experienced sexual abuse at the hands of an adult. While childhood sexual abuse is a widespread problem in itself, it is also known to have long-term eff...

The effect of acceptance and commitment therapy on insomnia and sleep quality: A systematic review.

Aug 17, 2020

Acceptance and Commitment Therapy (ACT), as a type of behavioral therapy, attempts to respond to changes in people's performance and their relationship to events. ACT can affect sleep quality by provi...

Theta Phase Synchrony Is Sensitive to Corollary Discharge Abnormalities in Early Illness Schizophrenia but Not in the Psychosis Risk Syndrome.

Aug 17, 2020

Prior studies have shown that the auditory N1 event-related potential component elicited by self-generated vocalizations is reduced relative to played back vocalizations, putatively reflecting a corol...

Is Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?

Aug 17, 2020

Nootropics are drugs used to either treat or benefit cognition deficits. Among this class, methylphenidate is a popular agent, which acts through indirect dopaminergic and noradrenergic agonism and, t...

Interprofessional Collaboration and Involvement of Parents in the Management of Painful Procedures in Newborns.

Aug 17, 2020

Newborns are subject to many painful procedures. Pharmacological and non-pharmacological approaches alone are not enough, and it is necessary to consider other contributing elements such as the envir...

Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons.

Aug 17, 2020

GABAergic interneurons (GINs) are a heterogeneous population of inhibitory neurons that collectively contribute to the maintenance of normal neuronal excitability and network activity. Identification ...

A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder.

Aug 17, 2020

Frustration is associated with impaired attention, heightened arousal, and greater unhappiness in youths with bipolar disorder (BD) vs. healthy volunteers (HV). Little is known about functional activa...

Olfactory markers for depression: Differences between bipolar and unipolar patients.

Aug 17, 2020

The aim of the study was to compare olfactory functions between unipolar and bipolar patients according to the thymic states (depressed, euthymic) and determine specific olfactory variations between t...

The impact of sexual abuse on psychopathology of patients with psychogenic nonepileptic seizures.

Aug 17, 2020

In the present study, we evaluated if the presence of sexual abuse in the clinical history of patients with psychogenic non-epileptic seizures (PNES) is associated with a different psychopathological ...

Emotional reactivity to war stressors: An experience sampling study in people with and without different psychiatric diagnoses.

Aug 17, 2020

There is a lack of knowledge regarding real-time emotional reactivity to high-intensity stressors, particularly in people with mental illness, a potentially vulnerable population. The current study ai...

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