Sep 28, 2020

Appropriate management of post-operative pain is an ongoing challenge in surgical practice. At present, systemic opioid administration is routinely used for analgesia in the post-operative setting. Ho...

Sep 28, 2020

Opioid agonist therapy (OAT) models are generally provided without consideration of how pre-treatment characteristics may be associated with outcome. Therefore, we aimed to first characterize longitud...

Sep 28, 2020

In the field of spectral imaging, numerous instruments use scanning-based technologies. However, the temporal dimension of these systems, whether to scan the spectrum or scan the scene, can be an issu...

Sep 28, 2020

Recently, mutations in the RNA polymerase III subunit A (POLR3A) have been described as the cause of the neonatal progeria or Wiedemann-Rautenstrauch syndrome (WRS). POLR3A has important roles in tran...

Sep 28, 2020

Neuropeptide S is a recently discovered peptide signaling through its receptor NPSR, which is expressed throughout the brain. Since NPSR activation increases dopaminergic transmission, we now tested i...

Sep 28, 2020

Spinal cord injury (SCI) is an area of key interest in military medicine but has not been studied among the US Army Special Forces (SF), the most elite group of US soldiers. SF soldiers make up a disp...

Sep 28, 2020

Anxiety in social interactions is an important factor in cigarette use and nicotine dependence. Metacognitions about smoking have been found to predict smoking behavior and may help understand the rel...

Sep 24, 2020

[F]FDOPA PET imaging has shown dopaminergic function indexed as K differs between antipsychotic treatment responders and non-responders. However, the theragnostic potential of this biomarker to identi...

Sep 24, 2020

Abnormalities in the complement system have been described in patients with schizophrenia, with those individuals having greater frequency of complement component 4A (C4A) alleles and higher C4A trans...

Sep 24, 2020

It has been proposed that different stages of bipolar disorder may be underpinned by distinct neurobiological substrates. However, structural neuroimaging studies in early stages of the illness are li...

Sep 24, 2020

Clinical research has consistently established mental health conditions (MHCs) as frequent comorbidities of epilepsy. However, the extent of economic burden of comorbid MHC in patients with focal seiz...

Sep 24, 2020

The relationship between cognitive function and relapse of affective episodes in bipolar disorder (BD) is rarely studied. The aim of this prospective, longitudinal, case-control study was to assess th...

Sep 24, 2020

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are highly prevalent and debilitating disorders. The high overlap on the symptomatic and neurobiological level led to ongoing deb...

Sep 24, 2020

To estimate health related quality of life (HRQOL) in patients with untreated cavernous malformation of the CNS (CCM).We performed a cross-sectional observational study on patients with CCM admitted t...

Sep 24, 2020

Opioid use disorder (OUD) represents a large and pervasive global public health challenge. Previous genetic studies have demonstrated the significant heritability of OUD and identified several single-...

Sep 24, 2020

Persistent post-surgical pain is common among patients undergoing surgery, is detrimental to patients' quality of life, and can precipitate long-term opioid use. The purpose of this randomized control...

Sep 24, 2020

To compare enhanced recovery after surgery (ERAS) and conventional care (CC) protocols on outcomes of laparoscopic hysterectomy (LH) performed in the afternoon.A single-center randomized controlled tr...

Sep 24, 2020

Aggregation of α-synuclein (α-syn) is one of the central hypotheses for Parkinson's disease (PD), therefore, its inhibition and disaggregation is an optimistic approach for the treatment of PD. Here...

Sep 24, 2020

Many mental illnesses share overlapping or similar clinical symptoms, confounding the diagnosis. It is important to systematically characterize the degree to which unique and similar changing patterns...

Sep 24, 2020

Valid blood pressure (BP) measurements are needed in post-stroke rehabilitation hospital units for the management of hypertension. Automated devices could be used to improve on usual care BP measureme...