Nov 30, 2020

Functional Movement Disorders (FMDs) are challenging to treat. We assessed the effect of multidisciplinary inpatient rehabilitation, involving motor retraining, psychotherapy and psychotropic medicati...

Nov 30, 2020

 Mood disorders are often accompanied by cognitive difficulties that impede patients' functional capacity. However, neuropsychological tests provide limited insight into patients' ability to tackle d...

Nov 30, 2020

Trace amine-associated receptor 1 (TAAR1) plays a critical role in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TAAR1 mo...

Nov 30, 2020

Childhood lead (Pb) intoxication is a global public health problem best known for producing deficits in learning and poor school performance. Human and preclinical studies have suggested an associatio...

Nov 30, 2020

Opioid overdose deaths remain high in the U.S. Despite having effective interventions to prevent overdose deaths, there are numerous barriers that impede their adoption. The primary aim of the HEALing...

Nov 30, 2020

Although there are numerous strategies to counteract the death of dopaminergic neurons in Parkinson's disease (PD), there are currently no treatments that delay or prevent the disease course, indicati...

Nov 30, 2020

The transcription factor NF-E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant and detoxification response. The association between Nrf2 activity and iron-related oxidative stre...

Nov 30, 2020

Measures of resting-state functional connectivity allow the description of neuronal networks in humans and provide a window on brain function in normal and pathological conditions. Characterizing neur...

Nov 30, 2020

Variable genomic breakpoints have been identified through the application of target-capture next-generation DNA sequencing (DNA NGS) for ALK/ROS1/RET fusion detection in non-small cell lung cancer (NS...

Nov 30, 2020

The executive control network is involved in novel situations or those in which prepotent responses need to be overridden. Previous studies have demonstrated that when control is exerted, conscious pe...

Nov 30, 2020

Parkinson's disease is associated with a variety of dermatologic disorders and the study of skin may provide insights into pathophysiological mechanisms underlying this common neurodegenerative disord...

Nov 30, 2020

Postpartum depression affects 10 up to 15 % of women of childbearing age in industrialized countries and presents significant public health problem which leads to short and long-term consequences for ...

Nov 27, 2020

“There are important reasons to study chronic pain and PTSD together,” says Matthew J. Bair, MD, MS. Chronic pain and PTSD co-occur frequently. This comorbidity leads to significant adverse effec...

Nov 27, 2020

Antidepressant treatment trugs include selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). The incidences of SSRI-induced suicides date back to th...

Nov 27, 2020

Benzodiazepines are a class of drugs commonly used to treat insomnia and anxiety. But long-term use of benzodiazepines has been associated with several risk factors. This study aims to investigate the...

Nov 26, 2020

Structural brain alterations have been repeatedly reported in schizophrenia; however, the pathophysiology of its alterations remains unclear. Multivariate pattern recognition analysis such as support ...

Nov 26, 2020

Emerging evidence highlighted the essential role played by the microbiota-gut-brain axis in maintaining human homeostasis, including nutrition, immunity, and metabolism. Much recent work has linked th...

Nov 26, 2020

The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transpo...

Nov 26, 2020

Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an important limbic system structure that plays a key role in co...

Nov 26, 2020

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive decline of memory and cognitive function. The disease is characterized by the presence of amyloid plaques, tau...