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Addictions

Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.

Feb 17, 2020

It was suggested that D, L-Methadone might improve the clinical course of glioma patients. Owing to massive press coverage, patients demand the prescription of D, L-Methadone, but regarding its adjunc...

A randomised, double-blind, crossover, dose ranging study to determine the optimal dose of oral opioid to treat breakthrough pain for patients with advanced cancer already established on regular opioids.

Feb 17, 2020

Pain in people with advanced cancer is prevalent. When a stable dose of opioids is established, people still experience episodic breakthrough pain for which dosing of an immediate release opioid is us...

Associations between Neighborhood-Level Factors and Opioid-Related Mortality: A Multilevel Analysis using Death Certificate Data.

Feb 17, 2020

To identify associations between opioid-related mortality and neighborhood-level risk factors.Cross-sectional study.Massachusetts, USA.Using 2011-2014 Massachusetts death certificate data, we identifi...

Phosphates in medications: Impact on Dialysis Patients


Feb 13, 2020

Maintaining phosphorus balance in in-center hemodialysis (ICHD) patients is problematic despite recommended dietary restriction, dialysis, and phosphate binder use. Rarely is P content in prescribed m...

Neuroendocrine Effects of Naltrexone Versus Nalmefene

Feb 13, 2020

Naltrexone and nalmefene are approved for the treatment of alcohol use disorders, in different countries. Naltrexone is also approved for the treatment for opioid use disorders, most recently in a dep...

Estimating the impact of wide scale uptake of screening and medications for opioid use disorder in US prisons and jails.

Feb 13, 2020

Medications for opioid use disorder (OUD) are the most effective treatment for OUD, but uptake of these life-saving medications has been extremely limited in US prisons and jail settings, and limited ...

Trajectories of Retention in Opioid Agonist Therapy

Feb 13, 2020

Long-term engagement in opioid agonist therapy (OAT) has been consistently associated with reduced risk for morbidity and mortality in people with opioid use disorder (OUD). However, the dynamic natur...

Psychosocial Factors Associated with Sleep Quality and Duration Among Older Adults with Chronic Pain.

Feb 13, 2020

Sleep complaints are common among older adults with chronic pain. Because of the risk of significant side effects, sleep medications are not recommended as first-line treatments. Little is known about...

Opioid Crisis Along Mexico's Northern Border: Treatment Needs Mexican Opioid Crisis.

Feb 10, 2020

Heroin production for external markets and low rates of use in Mexico have had a long history. A recent shift toward an increase in use and related problems calls for the evaluation of treatment needs...

Opioid Prescribing Patterns of Oral and Maxillofacial Surgery Residents

Feb 10, 2020

The aim of this study was to report on the opioid prescribing patterns of oral and maxillofacial surgery residents for routine office-based procedures.A survey was sent to current resident members of ...

The impact of the abuse-deterrent reformulation of extended-release OxyContin on prescription pain reliever misuse and heroin initiation.

Feb 10, 2020

The introduction of abuse-deterrent OxyContin in 2010 was intended to reduce its misuse by making it more tamper resistant. However, some studies have suggested that this reformulation might have had ...

Nonpharmacological Adjunctive Treatment for Postpartum Women with Opioid Use Disorder

Feb 10, 2020

Over the past decade, opioid use disorder (OUD) among pregnant women has increased by over 400%. Although medication assisted treatment (MAT) provides necessary care for women with OUD, effective adju...

Mental health conditions and the risk of chronic opioid therapy among patients with rheumatoid arthritis: a retrospective veterans affairs cohort study.

Feb 10, 2020

Patients with rheumatoid arthritis (RA) often receive opioid analgesics for pain management. We examined the association between mental health conditions and the risk of chronic opioid therapy.A retro...

Cannabis-Associated Acute Illness

Jan 30, 2020

Although an understanding of the adverse effects that occur when new drugs become available or their availability increases—such as with the legalization of recreational cannabis use—is important,...

Smoking tied to worse outcomes after a stroke

Jan 14, 2020

By Lisa Rapaport People who smoke or have recently quit have higher odds of being severely impaired after a stroke than their counterparts who never smoked, a new study su...

FDA Approves Ubrelvy for Acute Migraine Treatment

Jan 08, 2020

Significantly more patients treated with Ubrelvy versus placebo achieved pain freedom two hours post-treatment TUESDAY, Dec. 24, 2019 (HealthDay News) -- Ubrelvy (ubrogepant) tablets have been ap...

Overdose, Relapse After Buprenorphine Discontinuation High

Dec 27, 2019

The longer patients continue with buprenorphine treatment, the lower their risk of adverse outcomes.   THURSDAY, Dec. 26, 2019 (HealthDay News) -- Buprenorphine treatment may be needed ...

Naltrexone Implant Helps HIV Patients Prevent Opioid Relapse

Apr 19, 2019

FRIDAY, April 19, 2019 (HealthDay News) -- Slow-release implantable naltrexone is associated with better outcomes than the oral drug for HIV-positive patients with an opioid addiction, according to a ...

One in Three U.S. Adults Aged 35 to 44 May Have Drinking Problem

Apr 17, 2019

WEDNESDAY, April 17, 2019 (HealthDay News) -- Adults in their mid-30s to 40s are drinking too much too often, according to survey results released by the American Osteopathic Association. The Harris ...

Alcohol, Drug Misuse Tied to Long-Term Health Problems

Apr 08, 2019

MONDAY, April 8, 2019 (HealthDay News) -- More than one-third of U.S. adults in recovery for alcohol and other drug (AOD) use have health problems related to previous substance use, according to a stu...