Advertisement
[adinserter block="11" template="Global Header" check="exceptions" ignore="page-type"]

Addictions

Social Disadvantages Linked to SUD Inequities

Apr 30, 2024

An analysis published in Addiction and Research Theory suggests that individual factors and social determinants of health, such as mental illness, socioeconomic status, and criminal justice involvemen...

Enhancing drug checking services for supply monitoring: perspectives on implementation in syringe service programs in the USA.

Jan 15, 2024

Shifts in the US drug supply, including the proliferation of synthetic opioids and emergence of xylazine, have contributed to the worsening toll of the overdose epidemic. Drug checking services offer ...

#VisualAbstract: Lower rates of medication treatment for opioid use disorder in Black and Hispanic patients

Jun 14, 2023

Bookmark1. In this retrospective study of Medicare claims data from 2016 to 2019, receipt of opioid use disorder (OUD) medications (buprenorphine and naloxone) was lower among Black and Hispanic patie...

#VisualAbstract: Effectiveness of stand-alone telephone-delivered intervention for reducing problem alcohol use

Oct 11, 2022

1. In this randomized controlled trial, in participants with problem alcohol use, individuals in the active control group, receiving brief check-ins, and the intervention group, receiving teleheal...

Healthcare Exposure Ups Opioid Misuse Risk in Young Adults

Jun 24, 2022

Young adults exposed to inpatient hospitalizations, EDs, or mental health facilities had an increased risk for opioid misuse later in adulthood. Opioid misuse increased dramatically throughout ...

Alcohol Misuse Linked to Poorer Treatment Response in Psoriasis

Oct 26, 2021

“Treatment effectiveness of conventional oral therapies, and of the newer biologic treatments, for moderate-to-severe psoriasis is much lower in real-world clinical practice than in clinical trials,...

A peripheral antinociceptive effects of a bifunctional μ and δ opioid receptor ligand in rat model of inflammatory bladder pain.

Jul 15, 2021

There is a need to develop a novel analgesic for pain associated with interstitial cystitis/painful bladder syndrome (IC/PBS). The use of the conventional μ-opioid receptor agonists to manage IC/PBS ...

Sex differences in neuroimmune and glial mechanisms of pain.

Jul 15, 2021

Pain is the primary motivation for seeking medical care. Although pain may subside as inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain state can occur ...

Hepatocellular Carcinoma: The Alcohol Pathway for the 4th Leading Cancer-Related Cause of Death

Feb 18, 2021

Hepatocellular carcinoma (HCC) is the fourth most prevalent cause of cancer-related death worldwide, and incidence in the US has tripled in the last 4 decades. Excessive alcohol consumption is one the...

Automated quantification of opioid withdrawal in neonatal rat pups using Ethovision® XT software.

Feb 04, 2021

Chronic prenatal exposure to opioids often causes fetal opioid dependence that leads to neonatal opioid withdrawal syndrome (NOWS) shortly after delivery. Rat models of NOWS often require quantifying ...

Anxiety sensitivity and substance use: Differential levels across individuals primarily using opioids, cannabis, or stimulants.

Jan 28, 2021

The purpose of the current study was to compare levels of anxiety sensitivity (AS) across a treatment-seeking sample of individuals primarily using opioids, stimulants, or cannabis. Consistent with th...

Study Connects the Dots Between Smoking and Stroke Risk in African Americans

Jun 12, 2020

Risk increases as more cigarettes are smoked According to the Office of Minority Health of the Health and Human Services Administration, African Americans are 50% more likely to have a stroke than th...

How COVID-19 Has Impacted the Opioid Crisis

May 07, 2020

When it comes to rates of infection and addiction, both the coronavirus pandemic and the opioid epidemic disproportionately impact the poorest and most vulnerable members of society. As physicians, it...

Mental Disorders May Up Risk for Subsequent Medical Conditions

Apr 30, 2020

THURSDAY, April 30, 2020 (HealthDay News) -- The presence of a mental disorder is associated with an increased risk for many subsequent medical conditions, according to a study on a Danish population ...

Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca dependent manner.

Apr 28, 2020

Receptor-operated activation of TRPC4 cation channels requires G proteins and phospholipase-Cδ1 (PLCδ1) activation by intracellular Ca Concurrent stimulation of G pathway accelerates G activation of...

Opioid tapering after surgery: a qualitative study of patients' experiences.

Apr 28, 2020

Background and aims Patients usually receive a prescription for morphine or another opioid at discharge after surgery. Several studies have shown that many patients do not step down but develop persis...

Military veterans with and without post-traumatic stress disorder: results from a chronic pain management programme.

Apr 28, 2020

Background and aims There is very little published evaluation of the treatment of military veterans with chronic pain, with or without post-traumatic stress disorder. Few clinical services offer integ...

Evaluation of communication to general practitioners when opioid-naïve post-surgical patients are discharged from hospital on opioids.

Apr 28, 2020

To address the opioid crisis, much work has focused on minimizing opioid supply to surgical patients upon hospital discharge. Research is limited regarding handover to primary care providers. The aim ...

Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway.

Apr 28, 2020

Hypoxia induces reversible κ-opioid receptor (KOR) internalization similar to the internalization that is induced by KOR agonists. In the current study, we demonstrate that this KOR internalization i...

Breast surgery and peripheral blocks. Is it worth it?

Apr 24, 2020

The objective of this review is to identify the potential of peripheral nerve blocks established over the last years for perioperative pain management in breast surgery. These new blocks will be discu...