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Pain General

Comorbidities & Risk of Migraine Progression

May 05, 2020

Research indicates that Chronic migraine (CM; ≥15 monthly headache days with 8 or more linked to migraine) is associated with higher rates of disability and comorbidities, as well as reductions in h...

A Novel Virtual Reality Approach to CRPS

May 03, 2020

Chronic pain affects an estimated 20% of people worldwide and remains difficult to treat. Although previous studies suggest that altering the central representation of the body through multisensory bo...

Many Legal Marijuana Products Too Strong for Treating Pain

Apr 03, 2020

FRIDAY, April 3, 2020 (HealthDay News) -- Legally dispensed marijuana products have stronger concentrations of tetrahydrocannabinol (THC) and cannabidiol (CBD) than needed for chronic pain relief, acc...

External Trigeminal Nerve Stimulation for VM

Apr 01, 2020

Despite being the most common neurologic cause of vertigo in adults, no FDA-approved treatments are available for vestibular migraine (VM) and few studies have assesses possibly effective rescue treat...

Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review.

Mar 23, 2020

The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported...

The method simulating spontaneous pain in patients with nociplastic pain using rats with fibromyalgia-like condition.

Mar 23, 2020

The method shown in this article simulates spontaneous pain in patients with nociplastic pain using rats; the measurement with this method could be related to better translation of analgesic efficacie...

Effects of exergames on heart rate variability of women with fibromyalgia: A randomized controlled trial.

Mar 23, 2020

The objective of the present manuscript was to evaluate the effects of 24-weeks exergame intervention on the heart rate variability (HRV) of women with fibromyalgia. First, 56 women with fibromyalgia ...

The contribution of motor commands to the perturbations induced by sensorimotor conflicts in fibromyalgia.

Mar 23, 2020

Individuals with pain report higher sensory disturbances during sensorimotor conflicts compared to pain-free individuals. In the pain field, it is frequently assumed that disturbances arise from a dis...

Efficacy and safety of immediate oral intake in patients with mild acute pancreatitis: A randomized controlled trial.

Mar 23, 2020

Early enteral nutrition is recommended for patients with severe acute pancreatitis (AP); however, nutritional management strategies for patients with mild AP have not been established. The aim of this...

A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches.

Mar 23, 2020

Migraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phon...

FERM domain-containing protein 6 identifies a subpopulation of varicose nerve fibers in different vertebrate species.

Mar 23, 2020

FERM domain-containing protein 6 (FRMD6) is a member of the FERM protein superfamily, which is evolutionary highly conserved and has recently been identified as an upstream regulator of the conserved ...

Contactless treatment for scoliosis by electromagnetically controlled shape-memory alloy rods: a preliminary study in rabbits.

Mar 23, 2020

To evaluate the safety and efficacy of a system aiming to correct scoliosis called "electromagnetically controlled shape-memory alloy rods" (EC-SMAR) used in a rabbit model.We heat-treated shape-memor...

Changes in sales of analgesics to pharmacies after codeine was rescheduled as a prescription only medicine.

Mar 23, 2020

To investigate changes in sales to pharmacies of over-the-counter (OTC) and prescription analgesics, cold and flu products, and cough suppressants after the rescheduling of codeine as a prescription o...

Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.

Mar 23, 2020

Psoriasis is the most common chronic inflammatory condition involving the T helper cell system. Population studies have demonstrated that patients with psoriasis and/or psoriatic arthritis have an inc...

The microbiome and rheumatoid arthritis.

Mar 23, 2020

Rheumatoid Arthritis (RA) is a severe, chronic autoimmune disease that affects 1% of the world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest risks seen in ...

Challenges in the clinical diagnosis of psoriatic arthritis.

Mar 23, 2020

Psoriatic arthritis (PsA) is a chronic heterogeneous inflammatory musculoskeletal disease. The non-specific and often subtle manifestations make early diagnosis and subsequent treatment challenging. I...

Effectiveness of the use of an algorithm in the diagnostic approach of joint pain patients by primary care physicians.

Mar 23, 2020

There is a high percentage of error in the approach of patients with joint pain by primary care physicians. An algorithm can help improve this misdiagnosis problem. Our study seeks to determine the ef...

Treatment of chronic neuropathic pain: purine receptor modulation.

Mar 23, 2020

Extracellular nucleosides and nucleotides have widespread functions in responding to physiological stress. The "purinome" encompasses four G protein-coupled receptors (GPCRs) for adenosine, eight GPCR...

Are weather conditions associated with chronic musculoskeletal pain? Review of results and methodologies.

Mar 23, 2020

Many people believe that weather influences chronic musculoskeletal pain. Previous studies on this association are narratively reviewed, with particular focus on comparing methodologies and summarisin...

Nicotinamide adenine dinucleotide phosphate oxidase 2-derived reactive oxygen species contribute to long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high-frequency stimulus of the sciatic nerve.

Mar 23, 2020

High-frequency stimulation (HFS) of the sciatic nerve has been reported to produce long-term potentiation (LTP) and long-lasting pain hypersensitivity in rats. However, the central underlying mechanis...

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